Case study: acute basal ganglia enlargement and obsessive-compulsive symptoms in an adolescent boy.

Journal of the American Academy of Child and Adolescent Psychiatry,  July, 1996  by Swedo, Susan E.

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Converging lines of evidence support basal ganglia dysfunction as a basis for at least some forms of obsessive-compulsive disorder (OCD) (Baxter, 1992; Insel, 1992; Modell et al., 1989; Wise and Rapoport, 1989). More recently, Sydenham's chorea has been proposed as a model of OCD in which basal ganglia dysfunction is hypothesized to be mediated through an autoimmune response to group A [Beta]-hemolytic streptococcal (GABHS) infection (Allen et al.

1995; Swedo, 1994; Swedo et al., 1994). The present report is of a boy with a postinfectious exacerbation of his OCD, who had serial ...

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