Case Study: Caudate Glutamatergic Changes With Paroxetine Persist After Medication Discontinuation in Pediatric OCD.

Journal of the American Academy of Child and Adolescent Psychiatry,  August, 2001  by ROSENBERG, DAVID R.

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ABSTRACT

Proton magnetic resonance spectroscopy ([H.sup.1]-MRS) was used to examine glutamatergic (Glx) abnormalities in the caudate nucleus in pediatric obsessive-compulsive disorder (OCD), associated with severity of illness and response to acute (12 weeks) treatment with paroxetine. In this report, OCD symptoms improved markedly in an 8-year-old girl treated for 14 months with the selective serotonin reuptake inhibitor paroxetine (titrated from 10 to 40 mg/day). Paroxetine dose was then decreased in 10-mg decrements and discontinued without symptom recurrence. Serial ...

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