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Industry: Email Alert RSS FeedBupropion (Zyban). (Medication Update).(Brief Article)
Southern Medical Journal, April, 2002 by Slagle, Mark
Mode of Action for Smoking Cessation
Mechanism of action is unclear, but may be related to noradrenergic and/or dopaminergic activity of bupropion. The quit rate at week seven of therapy ranges from 27% to 49%. In one dose-response trial conducted by the manufacturer, the quit rate at week 26 was 18%, which was not statistically superior to placebo.
Contraindications
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Known hypersensitivity to bupropion, or any component of the formulation. Should never be used in a patient with a seizure disorder, anorexia, or bulimia. Should not be given to patients already taking ...
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