COX-2s questioned as GI panacea.

Australian Doctor,  May, 2006  

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By Jane McCredie

THE claimed gastrointestinal advantages of COX-2 inhibitors have been cast into further doubt, with research suggesting an NSAID and proton pump inhibitor combination offers a greater reduction in risk of dyspepsia.

"Our data provide a strong clinical and economic rationale for substituting the NSAID plus PPI combination in lieu of coxibs in high-risk patients with arthritis," the authors of a meta-analysis comparing the two treatment options wrote in the American Journal of Medicine (May).

Associate Professor Anne Duggan, director of ...

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