Oestrogen ups breast cancer at 15 years.

Australian Doctor,  May, 2006  

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By Jane McCredie

WOMEN on long-term hormone replacement therapy should have their breast health and risk-benefit profile evaluated regularly, an expert says, with a study finding a significant increase in breast cancer risk after 20 years of unopposed oestrogen therapy.

For oestrogen or progesterone receptor-positive cancers, a significant increase in risk was observed after 15 years' treatment, according to findings from the Nurses' Health Study reported in the Archives of Internal Medicine (8 May).

"We now have some data that shows the increased risk seems to start ...

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