PCOS treatment controversy.

Australian Doctor,  February, 2007  

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By Gabrielle Babbington

NEJM Clomiphene is three times more effective than metformin at achieving a live birth for infertile women with polycystic ovarian syndrome and should be used as first-line treatment, according to a landmark study that is dividing Australian experts.

The controversial finding -- from the largest study to date comparing the fertility effects of six months of treatment with clomiphene citrate, extended-release metformin or combination therapy using both drugs -- has turned the tables on previous research.

The multi-centre randomised trial of 626 ...

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