Method of Quantifying Lipid-Rich Vacuolated Macrophages in Peripheral Blood

A-2

N. Brooks, R. Devalaraja, C. Whitinger, S. Drake. Esperion Therapeutics, Division of Pfizer Global Research and Development, Ann Arbor, MI,

Peripheral blood examination from Wistar rats following treatment with agents enhancing cholesterol mobilization revealed large vacuolated mononuelear cells in toxicology studies, the goal of this study was to eharaeterize vacuolated mononuelear cells in peripheral blood smears and the vacuole contents. The monocyte scatter on the Cell-Dyn 3700 hematology analyzer revealed increased cell volume in the monocyte population. Buffy coat and peripheral blood ...

Read the rest of this article with a Free Trial at HighBeam Research.