The Fludrocortisone/Furosemide test - a safe, effective and well tolerated urine acidification test

Clinical Chemistry, June, 2006 by Karet, F E; Norden, A G; Viljoen, A

A-65

A. Viljoen, A. G. Norden, F. E. Karet. Addenbrookes Hospital, Cambridge, United Kingdom,

The ammonium chloride (NM^sub 4^Cl) urine acidification test has hecn the gold standard investigation tor exclusion of type I renal tubular acidosis (RTA) for over 50 years, hut it has significant side-effects such as emesis and abdominal pain, and so is less often performed than may he clinically indicated. The loop diuretic furosemide has been suggested as an alternative and more acceptable method of diagnosis based on the obligate secretion of protons into the urine when distal sodium delivery ...