Vaginal misoprostol administered at home after mifepristone for abortion - RU486

Journal of Family Practice, April, 1997 by Eric A. Schaff, Lisa S. Stadalius, Steven H. Eisinger, Peter Franks

* The earliest pregnancy identified by transvaginal ultrasound has a gestational sac of 2 to 3 mm corresponding to 32 to 33 days.

REFERENCES

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(2.) Peyron R, Aubeny E, Tarzus V, Silvestre L, Renault M, Elkik F et al. Early termination of pregnancy with mifepristone (RU-486) and orally active prostaglandin misoprostol. N Engl J Med 1993; 328:1509-13.

(3.) Thong KJ, Baird DT. Induction of abortion with mifepristone and misoprostol in early pregnancy. Br J Obstet Gynaecol 1992; 99:1004-7.

(4.) Winikoff B. Acceptability of medical abortion in early pregnancy. Fam Plann Perspect 1995; 185:142-8.

(5.) el-Refaey H, Templeton A. Early induction of abortion by a combination of oral mifepristone and misoprostol administered by the vaginal route. Contraception 1994;49:111-4.

(6.) el-Refaey H, Rajasekar D, Abdalla M, Calder L, Templeton A. Induction of abortion with mifepristone (RU486) and oral or vaginal misoprostol. N Engl J Med 1995; 332:983-7.

(7.) Aubeny E, Peyron R, Turpin CL, Renault M, Targosz V, Silvestre L, et al. Termination of early pregnancy (up to and after 63 days of amenorrhea) with mifepristone (RU486) and increasing doses of misoprostol. Int J Fertil Menopausal Stud 1995; 40:85-91.

(8.) Creinin MD, Vittinghoff E. Methotrexate and misoprostol vs misoprostol alone for early abortion, a randomized controlled trial. JAMA 1994; 272:1190-5.

(9.) Hausknecht RU. Methotrexate and misoprostol for induced abortion. N Engl J Med 1995; 333:537-40.

(10.) Schaff EA, Eisinger SH, Franks P, Kim S. Methotrexate and misoprostol for early abortion. Fam Med 1996; 28:198-203.

(11.) Lindblom B. Ectopic pregnancy: laparoscopic and medical treatment. Curr Opin Obstet Gynecol 1992; 4:400-5.

(12.) Stoval TG, Ling FW. Single-dose methotrexate: an expanded clinical trial. Am J Obstet Gynecol 1993; 168:1759-62.

(13.) Creinin MD, Darney PD. Methotrexate and misoprostol for early abortion. Contraception 1993; 48:339-47.

(14.) Goldstein SR. Embryonic ultrasonographic measurements: crown-rump length revisited. Am J Obstet Gynecol 1991; 165:497-50.

Eric A. Schaff, MD; Lisa S. Stadalius, RNC, MS; Steven H. Eisinger, MD; and Peter Franks, MD Rochester, New York

Submitted, revised, January 28, 1997.

From the Departments of Family Medicine, Pediatrics, and Obstetrics and Gynecology, and the School of Nursing, University of Rochester, Rochester, New York. Address correspondence to Eric A. Schaff, MD, Department of Family Medicine, University of Rochester, 885 South Ave, Rochester, NY 14620.