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Industry: Email Alert RSS FeedDrug treatment of epilepsy
British Medical Journal, Jan 9, 1999 by Morgan Feely
* The epilepsy is controlled, but the patient has problems with side effects and no change in the treatment (drug or dosage) is made
* The patient is seen by a specialist and referred back to the general practitioner with an appropriate recommendation regarding treatment, but when this proves ineffective further advice is not sought
Summary points
In treating epilepsy, the drug chosen needs to be matched to the individual patient and the type of epilepsy
Often, the most suitable treatment regimen can be established only by trial and error
The wide range of treatments now available offers most patients good seizure control without unacceptable side effects and offers patients with refractory epilepsy a chance of better control
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Many patients with epilepsy still do not seem to be getting the treatments that are most appropriate for them
Competing interests: During the past five years MF has attended epilepsy meetings abroad as a guest of the manufacturers of all four of the "new" drugs currently marketed in the United Kingdom.
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[2] Richens A, Perucca E. General principles in the drug treatment of epilepsy. In: A textbook of epilepsy. 4th ed. Edinburgh: Churchill Livingstone, 1993.
[3] Brodie MJ, Dichter MA. Established antiepileptic drugs. Seizure 1997;6:159-74.
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[5] Roberts SJ, Feely M, Bateman DN. Prescribing of anti-epileptic drugs in the northern and Yorkshire region 1992-1995. Seizure 1998;7:127-32.
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[7] Stephen LJ, Brodie MJ. New drug treatments for epilepsy. Prescribers J 1998;38:98-106.
[8] Brown TR, Mattson TH, Penry JK, Smith DB, Treiman DM, Wilder BJ, et al. A multicentre study of vigabatrin for drug-resistant epilepsy. Br J Clin Pharmacol 1989;27(suppl):95-100S.
[9] Brodie MJ, Richens A, Yuen AWC. Double-blind comparison of lamotrigime and carbamazepine in newly diagnosed epilepsy. Lancet 1995;345:476-9.
[10] UK Gabapentin Study Group. Gabapentin in partial epilepsy. Lancet 1990;335:114-7.
[11] The US Gabapentin Study Group No 5. Gabapentin as add-on therapy in refractory partial epilepsy. Neurology 1993;43:2292-8.
[12] Faught E, Wilder BJ, Ramsay RE, Reife RA, Kramer LD, Pledger GW, et al. Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200, 400 and 600 mg daily dosages. Neurology 1996;46:1684-90.
[13] Marson AG, Kadir ZA, Chadwick DW. New antiepileptic drugs: a systematic review of their efficacy and tolerability. BMJ 1996;313:1169-74.
[14] Brodie MJ. Lamotrigine versus other antiepileptic drugs: a star rating system is born. Epilepsia 1994;35:S41-6.
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