Decrease in anogenital distance among male infants with prenatal phthalate exposure

Environmental Health Perspectives, August, 2005 by Shanna H. Swan, Katharina M. Main, Fan Liu, Sara L. Stewart, Robin L. Kruse, Antonia M. Calafat, Catherine S. Mao, J. Bruce Redmon, Christine L. Ternand, Shannon Sullivan, J. Lynn Teague

REFERENCES

Barlow NJ, Foster PM. 2003. Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to di(n-butyl) phthalate. Toxicol Pathol 31:397-410.

Barlow NJ, McIntyre BS, Foster PM. 2004. Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate. Toxicol Pathol 32:79-90.

Bowman C J, Barlow N J, Turner KJ, Wallace DG, Foster PM. 2003. Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat. Toxicol Sci 74:393-406.

Callegari C, Everett S, Ross M, Brasel JA. 1987. Anogenital ratio: measure of fetal virilization in premature and full-term newborn infants. J Pediatr 111:240-243.

CDC. 2003. Second National Report on Human Exposure to Environmental Chemicals. Atlanta, GA:Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences.

Clark RL, Antonello JM, Grossman SJ, Wise LD, Anderson C, Bagdon WJ, et al. 1990. External genitalia abnormalities in male rats exposed in utero to finasteride, a 5 alpha-reductase inhibitor. Teratology 42:91-100.

Colon I, Caro D, Bourdony CJ, Rosario O. 2000. Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development. Environ Health Perspect 108:895-900.

Duty SM, Calafat AM, Silva MJ, Ryan L, Hauser R. 2005. Phthalate exposure and reproductive hormones in adult men. Hum Reprod 20:604-610.

Duty SM, Silva MJ, Barr DB, Brock JW, Ryan L, Chen Z, et al. 2003a. Phthalate exposure and human semen parameters. Epidemiology 14:269-277.

Duty SM, Singh NP, Silva MJ, Barr DB, Brock JW, Ryan L, et al. 2003b. The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay. Environ Health Perspect 111:1164-1169.

Ema M, Miyawaki E. 2001. Adverse effects on development of the reproductive system in male offspring of rats given monobutyl phthalate, a metabolite of dibutyl phthalate, during late pregnancy. Reprod Toxicol 15:189-194.

Ema M, Miyawaki E, Hirose A, Kamata E. 2003. Decreased anogenital distance and increased incidence of undescended testes in fetuses of rats given monobenzyl phthalate, a major metabolite of butyl benzyl phthalate. Reprod Toxicol 17:407-412.

Fisher JS. 2004. Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome. Reproduction 127:305-315.

Foster PM, Cattley BC, Mylchreest E. 2000. Effects of di-n-butyl phthalate (DBP) on male reproductive development in the rat: implications for human risk assessment. Food Chem Toxicol 38:S97-S99.

Foster PM, Lake BG, Thomas LV, Cook MW, Gangolli SD. 1981. Studies on the testicular effects and zinc excretion produced by various isomers of monobutyl-o-phthalate in the rat. Chem Biol Interact 34:233-238.

Foster PM, McIntyre BS. 2002. Endocrine active agents: implications of adverse and non-adverse changes. Toxicol Pathol 30:59-65.