Using A Cell-Culture Model To Understand Estrogen Receptor Regulation In Normal And Malignant Mammary Cells

Life Sciences & Biotechnology Update, Feb, 2001

This (University of California) paper characterizes a spontaneous epithelial-to-mesenchymal conversion (EMT) in the non-transformed `functional normal' mammary epithelial cell-line, SCp2, to determine if the mesenchymal conversion in SCp2 cells is associated with tumorigenesis. It determines if alterations in growth- factor expression and regulation are accompanied by changes in ECM and metalloproteinases expression, and if the presence of 3-D structure is critical to stopping spontaneous and induced conversion.

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