MAMMARY TUMORIGENESIS: INTERACTIONS OF TGFa-myc

Life Sciences & Biotechnology Update, Feb, 2001

This (Georgetown University) research studies the nature of the synergistic interaction of the growth factor TCFa and the nuclear protoonco-protein product c-Myc for bitransgenic mouse mammary tumorigenesis. Evidence is found of a multifactorial interaction of the two genes, involving: cooperative stimulation of proliferation; anchorage independent colony formation; suppression of cell death (apoptosis); and chromosomal destabilization. In addition, it is observed that the TGFalpha-related growth factors, amphiregulin and cripto-l, are likely to have tumor promoting effects similar to TGFalpha in breast cancer. Further studies address the ability of c-Myc and TGFalpha to interact in a novel paracrine mammary system in vivo. The research results in the development of a new model system whereby the interactions of two important genes in breast cancer may be dissected, in vivo, at the molecular level.

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