OTCBB Has Not Yet Set Ex-Dividend Date For Patient Infosystems, Inc. Distribution of American Caresource Holdings, Inc. Shares

Business Wire, Nov 9, 2005

ROCHESTER, N.Y. -- Patient Infosystems, Inc. (OTCBB: PATY - News) a healthcare services company today announced that the OTCBB has not yet established the Ex-Dividend Date (the "ExDate") for its dividend of American Caresource Holdings, Inc. common stock (the "Spin-off") until the registration statement relating to the distribution of the securities of American Caresource Holdings, Inc. ("ACS") is declared effective by the Securities and Exchange Commission.

Patient Infosystems has been advised by the OTCBB that any purchasers of its common stock before the ExDate will be entitled to receive from the seller thereof the dividend of ACS common stock in connection with the Spin-off. Patient Infosystems expects that the spin-off will occur as soon as practicable following the date that the registration statement filed by ACS with the Securities and Exchange Commission becomes effective.

American Caresource Holdings, Inc. is a comprehensive national ancillary benefit management company, offering a network in excess of 19,000 providers nationally. American Caresource Holdings, Inc. offers its payor clients substantial discounts on services rendered by ancillary care providers in more than 30 service categories including home care, durable medical equipment, infusion, outpatient physical therapies, chiropractors, dialysis, and others. American Caresource Holdings, Inc.'s ancillary network management and repricing services assist in achieving these objectives.

Patient Infosystems, Inc. is a leading health management solutions company. Our patient-focused solutions for health insurers and healthcare delivery organizations include integrated, proactive chronic condition management services, intensive management and case management, maternity management, smoking cessation and 24/7 nurse help line services. Our integrated model allows all the interventions of healthcare management to come together in one seamless system, producing efficiencies that drive improved health outcomes and reduce overall healthcare spending. For more information on Patient Infosystems, Inc. please go to www.ptisys.com.

A registration statement relating to these securities has been filed with the Securities and Exchange Commission but has not yet become effective. These securities may not be sold nor may offers to buy be accepted prior to the time the registration statement becomes effective. This press release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of these securities in any state in which such offer, solicitation or sale would be unlawful prior to registration under the securities laws of any such state.

A preliminary prospectus relating to the securities may be obtained at the offices of American Caresource Holdings, Inc., 8080 Tri-Star Drive, Irving, Texas 75063, attention David Boone.

Any statements that are not historical facts contained in this release are forward-looking statements. It is possible that the assumptions made by Patient Infosystems for purposes of such statements may not materialize. Such statements may involve risks and uncertainties, including but not limited to those relating to product demand, pricing, market acceptance, the effect of economic conditions, and intellectual property rights, and the outcome of competitive products, risks in product development, the results of financing effort, the ability to complete transactions, and other risks identified in this release, and the Securities and Exchange Commission filings of Patient Infosystems, Inc.