BARRX Medical, Inc. Secures $27.8 Million Series C Venture Funding; Investment to Help Advance Treatment of Barrett's Esophagus

Business Wire, July 20, 2006

SUNNYVALE, Calif. -- BARRX Medical, Inc. today announced the close of a $27.8 million Series C capital investment. Montagu Newhall Associates led the financing, which was joined by existing investors Delphi Ventures, Alloy Ventures, Frazier Healthcare Ventures, Sutter Hill Ventures and others. BARRX Medical, Inc. develops treatment solutions for Barrett's esophagus, a precancerous condition of the lining of the esophagus caused by gastroesophageal reflux disease, or GERD.

"We're pleased to receive growth capital from our current active investors and to welcome Mongtagu Newhall Associates to our team," said Greg Barrett, president and CEO of BARRX Medical Inc. "Our technology has the opportunity to alter the manner in which Barrett's esophagus is treated today and in the future. This funding will help BARRX Medical respond to increasing demand from physicians and medical centers for the HALO360 and the HALO90 Systems. Additionally, it will allow us to establish internal manufacturing operations and facilitate clinical trials investigating expanded use of the HALO System."

The HALO360 System represents a new type of tissue ablation solution. It provides uniform, controlled ablative therapy at a consistent depth to remove diseased esophageal tissue, allowing replacement by normal cells. The HALO90 System is uniquely able to treat smaller areas of Barrett's esophagus, offering a convenient, out-patient treatment option. Physicians can use the HALO360 and HALO90 Systems, based on the patient needs, to provide a safe, convenient solution for the complete removal of Barrett's esophagus.

Barrett's esophagus occurs when chronic acid reflux disease causes the cells lining the esophagus to transform and undergo genetic changes that can set the stage for cancer development. Barrett's has traditionally been managed with frequent endoscopic biopsy surveillance to detect progression to cancer. However, many physicians have recognized the need to proactively treat Barrett's esophagus, rather than watching and waiting for the potential progression of the disease. Ablation--the use of energy to remove the diseased layer of cells from the esophagus--offers treatment for Barrett's esophagus before it has the opportunity to progress to cancer. New healthy tissue replaces the ablated Barrett's tissue in three to four weeks for most patients.

Ashton Newhall, general partner at Montagu Newhall Associates, said: "We're excited by the opportunity to fund the growth of BARRX Medical and believe the company has exceptional potential. Barrett's esophagus is a serious condition and we are eager to be involved in changing the landscape of its treatment."

About BARRX Medical, Inc.

BARRX Medical, Inc. develops treatment solutions for Barrett's esophagus, a precancerous condition of the lining of the esophagus (swallowing tube) caused by gastroesophageal reflux disease, or GERD. Its flagship product, the HALO360 System, provides uniform and controlled therapy at a consistent depth, which can remove Barrett's esophagus and allow the regrowth of normal cells. In the largest study conducted, 70 percent of patients were Barrett's-free (at twelve- month follow up). The system used in the clinical trials was cleared by the U.S. Food and Drug Administration in 2001 and has been commercially available since January 2005. Based in Sunnyvale, Calif., BARRX Medical, Inc. was founded in 2000 and is privately-held. Additional information about BARRX Medical, Inc. and the HALO360 System is available at www.barrx.com.