Safeguard to File Form 12B-25 to Extend Filing Due Date of Its 2006 Annual Report on Form 10-K

Business Wire, March 19, 2007

Expects to File Within Automatic 15-Day Extension Period

WAYNE, Pa. -- Safeguard Scientifics, Inc. (NYSE: SFE), a holding company which builds value in growth-stage technology and life sciences companies, announced that today it will file a Form 12b-25, Notification of Late Filing, with the Securities and Exchange Commission (SEC) for its Annual Report on Form 10-K for the year ended December 31, 2006. This filing extends the March 16, 2007 filing due date for up to fifteen calendar days under SEC rules.

Safeguard's Form 10-K is required to include financial and other information concerning Clarient, Inc. (Nasdaq: CLRT), a majority-owned subsidiary. Clarient files reports with the SEC, but is not an accelerated filer. Therefore, its 2006 Annual Report on Form 10-K is not yet due. During the first quarter of 2007, Clarient sold its instrument business for approximately $12.5 million and completed several significant financing transactions, all of which caused delays in the completion of its financial statements. As a result, Clarient has not yet completed preparation of its 2006 Annual Report on Form 10-K. Safeguard currently anticipates that Clarient's financial and other information will be available within the 15-day period provided by Rule 12b-25 and that Safeguard will be able to file its Annual Report on Form 10-K within that period.

Additionally, Safeguard currently expects that the results of operations to be reported in its 2006 Annual Report on Form 10-K will be substantially consistent with the results reported in the company's fourth quarter 2006 earnings press release on March 8, 2007.

About Safeguard

Safeguard Scientifics, Inc. (NYSE: SFE) a holding company which builds value in growth-stage technology and life sciences businesses. We provide growth capital as well as a range of strategic, operational and management resources to our partner companies. Safeguard participates in expansion financings, corporate spin-outs, management buyouts, recapitalizations, industry consolidations and early-stage financings. www.safeguard.com

Except for the historical information and discussions contained herein, statements contained in this release may constitute "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Our forward-looking statements are subject to risks and uncertainties. These forward-looking statements that could cause actual results to differ materially, include, among others, longer than expected delays in Clarient's completion of its financial statements and Annual Report on Form 10-K, which could result in longer than expected delays in the filing of the Company's Annual Report on Form 10-K, changes in Clarient's results of operations for 2006 as compared to the results reported in its press release dated March 7, 2007, which could result in changes to Safeguard's consolidated results of operations for 2006 as compared to the results reported in the Company's March 8, 2007 press release, and certain other factors described in the Company's filings with the Securities and Exchange Commission. Many of these factors are beyond our ability to predict or control. In addition, as a result of these and other factors, our past financial performance should not be relied on as an indication of future performance. The Company does not assume any obligation to update any forward-looking statements or other information contained in this press release.