Amgen Receives Proposal for Amending EU Prescribing Information for Aranesp®

Business Wire, Sept 27, 2007

Patients receiving ESAs pre-operatively for reduction of allogeneic red blood cell transfusions: A higher incidence of deep venous thrombosis was documented in patients receiving Epoetin alfa who were not receiving prophylactic anticoagulation. Aranesp([R]) is not approved for this indication.

Aranesp is contraindicated in patients with uncontrolled hypertension.

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