Obesity Drug Discoveries: What the Future Holds

Business Wire, Sept 5, 2007

DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reports/c67503) has announced the addition of Obesity Drug Discoveries: What the Future Holds to their offering.

While only recently identified as a major health concern, obesity levels have been growing steadily and the condition threatens to rank among the biggest causes of premature death in both the industrialised and emerging economies. With only three products approved worldwide for long-term treatment, and growing unmet clinical need, the treatment of obesity could present a major opportunity area for pharma companies.

Obesity has reached epidemic proportions worldwide. With 2005 estimates of approximately 1.6 billion adults (aged 15 years and over) overweight and at least 400 million adults obese, the World Health Organization predicts that by 2015, approximately 2.3 billion adults will be overweight and more than 700 million will be obese. These estimates do not even take into account a lower overweight threshold set for Asians. In the US and Canada half of all adults are likely to be obese within eight years, with only one in five people of healthy weight.

The market for weight-loss drugs in the US, Europe and Japan totalled around US$600 million in 2005, and is expected to rise globally to approximately US$2 billion by 2010. Current long-term treatments include: Abbott's Meridia/Reductil (sibutramine), a monoamine reuptake inhibitor that is approved in the US and Europe; Roche's Xenical (orlistat), a gastric lipase inhibitor that is approved in the US and Europe; and sanofi-aventis' Acomplia (rimonabant), a cannabinoid type 1 receptor blocker that is approved only in Europe.

No single major company dominates the obesity drug market, although sanofi-aventis, GSK, Merck & Co and Pfizer all have several compounds in development. The rewards are high for those who can bring effective treatments to market, but questions remain...

- What are the strengths and weaknesses for current therapy approaches?

- Which research approach is likely to achieve best clinical and commercial results and when are the resulting drugs likely to reach the market?

- What are the development and regulatory challenges companies must overcome?

The answers to these and many other questions can be found in this new 120+ page strategic management report Obesity Drug Discoveries: What the future holds (published August 2007). In addition, for those needing to monitor this developing area there is the Obesity Tracker, an online news service available for customers buying the web edition of the report.

The race is on among competing research strategies

Obesity offers pharmaceutical companies a marketplace characterised by rapid and continuing growth, long-term unmet clinical need and a wide prevalence profile. The recognition of obesity as a serious global issue is relatively recent, and rising concern and interest has outpaced the industry's ability to nurture products through the lengthy regulatory process.

Health payers will have to balance the cost of obesity treatment with the very real health benefits of reducing related conditions, such as diabetes and cardiovascular disease. With pressure to contain rising drug costs, arguments about paying for this "lifestyle" illness are bound to rage.

Furthermore, patient demand for drug-based intervention, even for those with a questionable clinical need, could significantly boost the market value.

Although 25 companies have products in clinical development, much interest lies in the research and prospects of big pharma companies such as GSK, sanofi-aventis, Merck & Co and Pfizer. However, in such a fledgling market, the opportunities for innovation to win through are better than in established and more exploited therapy areas.

Report breakdown

Foreword

Executive summary

What is obesity?

Prevalence of obesity

Childhood and future obesity

The obesity therapy market

Obesity management

- Acomplia

- Meridia/Reductil

- Xenical/alli

Drugs in clinical development:

- KR P-204 (N-5984)

- CP-945,598

- Taranabant

- AVE 1625

- SLV 319

- Cetilistat

- 8696

- OBE 101

- Pramlintide

- Liraglutide

- Obinepitide

- PYY 3-36

- Lorcaserin

- Tesofensine

- S-2367

- Contrave

- Qnexa

- Pramlintide+phentermine/sibutramine

- Empatic

Recently-terminated programmes:

- AMG 076

- AOD 9604

- CP-741952

- CYT 009-GhrQb

- Oleoyl-estrone

- PF-431499

The future of obesity treatment

Conclusions

Sources

Companies mentioned:

- GSK

- Sanofi-aventis

- Alizyme/Takeda

- OREXIGEN Therapeutics

- Pfizer

- OREXIGEN Therapeutics

- Kyorin

- Novo Nordisk

- Arena Pharmaceuticals

- OBEcure

- 7TM Pharma

- Amylin Pharmaceuticals

- Nastech Pharmaceutical

- VIVUS

- Shionogi

- Solvay/BMS

- Merck & Co

- NeuroSearch

For more information visit http://www.researchandmarkets.com/reports/c67503.