Business Services Industry

MitoSciences Inc. and University of Oregon Complete Biotechnology Deal

Business Wire, April 15, 2008

Agreement Strengthens the Sharing of Monoclonal Antibodies with Life Science Researchers Around the World

EUGENE, Ore. -- The biotechnology company MitoSciences Inc. and the University of Oregon today announced the completion of an exclusive commercial license for a suite of biotechnology innovations.

The agreement centers on a portfolio of monoclonal antibodies -- specialized proteins that bind to specific biological molecules -- that were developed at the UO. Researchers and drug companies around the world now use the licensed antibodies to study disorders such as diabetes, Parkinson's and Alzheimer's diseases, cancer and variety of rare but debilitating genetic disorders.

Under the agreement, the University of Oregon will maintain its pre-existing equity position in MitoSciences and will receive royalties on patent-related sales and fixed, quarterly cash payments that could total $4.6 million should the company elect to continue to support its distribution of the antibodies over the next decade.

The university will transfer to MitoSciences several commercial distribution agreements through which the UO previously delivered antibodies to life-science researchers. MitoSciences also will be responsible for on-going maintenance, production and future distribution of the antibodies. The company also will receive exclusive commercialization rights for a portfolio of related UO biological assets, plus an exclusive license under several university patents that cover the use of monoclonal antibodies that recognize mitochondrial antigens.

"The University of Oregon has been a valued supporter of MitoSciences," said MitoSciences President Jean-Paul Audette, "and this agreement provides us with access to technology that will allow MitoSciences to continue to concentrate on research and development, and which we hope will have benefits for the diagnosis and treatment of diseases with metabolic etiologies."

The UO monoclonal antibodies covered in the agreement help to provide insights into the health and function of mitochondria, the microscopic energy factories that power human and animal cells. Creation of these antibodies resulted from a longstanding scientific collaboration between Roderick Capaldi, an internationally-recognized researcher at the UO's Institute of Molecular Biology, and Michael Marusich, director of the UO's Monoclonal Antibody Facility.

"At its core, this agreement with MitoSciences is a testament to the keen scientific insight, innovative spirit and perseverance of Rod, Mike and their coworkers," said Don Gerhart, associate vice president for research and innovation at the University of Oregon.

In 2003 Marusich and Capaldi created MitoSciences, a private company focused on developing tools for drug discovery, in-vitro diagnostics and life-science research. MitoSciences has since expanded and now employs more than 20 employees at its site in UO's Riverfront Research Park.

"MitoSciences is a great example of how scientific research at the University of Oregon can spin out innovative new ventures that contribute to our community," said Rich Linton, UO's vice president for research. "Through private-sector connections such as these, the University of Oregon can maintain its focus on basic research while simultaneously ensuring that our institution makes the fruits of federally sponsored research available to the private sector for the development of innovative products and services that strengthen Oregon's economy and deliver benefit to our citizens."

About MitoSciences Inc.

MitoSciences is a developer and manufacturer of monoclonal antibodies and immunoassays for use in understanding mitochondrial function and metabolism. MitoSciences' products are used by pharmaceutical companies, clinical laboratories and basic researchers to unlock the role of metabolic enzymes in disease, drug therapy and drug toxicology. With an emphasis on developing assays that can measure multiple parameters in a single sample, MitoSciences is supporting the rapidly growing fields of systems biology and personalized medicine.

About the University of Oregon

The University of Oregon is a world-class teaching and research institution and Oregon's flagship public university. The UO is a member of the Association of American Universities (AAU), an organization made up of 62 of the leading public and private research institutions in the United States and Canada. Membership in the AAU is by invitation only. The University of Oregon is one of only two AAU members in the Pacific Northwest.

Links: MitoSciences Inc.: http://www.mitosciences.com/; UO Institute of Molecular Biology: http://www.molbio.uoregon.edu/.>