Pygeum africanum - Prunus africana - African plum tree - Monograph: Pygeum africanum

Alternative Medicine Review, Feb, 2002

Dosage

P. africanum extract is usually administered at a dose (standardized to contain 14% triterpenes including beta-sitosterol and 0.5 % n-docosanol) of 50-100 mg twice daily. (18) The efficacy of Pygeum extract at 50 mg twice daily and 100 mg once daily has been shown to be equivalent. (12)

References

(1) Simons AJ, Dawson IK, Dugumba B, Tchoundjeu Z. Passing problems: prostate and prunus. HerbalGram 1998;43:49-53.

(2) Isaacs JT. Importance of the natural history of benign prostatic hyperplasia in the evaluation of pharmacologic intervention. Prostate 1990:3:1-7.

(3) Ishani A, MacDonald R, Nelson D, et al. Pygeum africanum for the treatment of patients with benign prostatic hyperplasia: a systematic review and quantitative meta-analysis. Am J Med 2000; 109:654-664.

(4.) Andro MC, Riffaud JP. Pygeum africanum extract for the treatment of patients with benign prostatic hyperplasia: a review of 25 years of published experience. Curr Ther Res 1995;56:796-817.

(5.) Murray MT The Healing Power of Herbs. Rocklin, CA: Prima Publishing; 1995:286-293.

(6.) Paubert-Braquet M, Cave A, Hocquemiller R, et al. Effect of Pygeum africanum extract on A23187-stimulated production of lipoxygenase metabolites from human polymorphonuclear cells. J Lipid Mediat Cell Signal 1994;9:285-290.

(7.) Robinette CL. Sex-hormone induced inflammation and fibromuscular proliferation in the rat lateral prostate. Prostate 1988;12:271-286.

(8.) Paubert-Braquet M, Monboisse JC, Servent-Saez N, et al. Inhibition of bFGF and EGF-induced proliferation of 3T3 fibroblasts by extract of Pygeum africanum (Tadenan). Biomed Pharmacother 1994;48:43-47.

(9.) Desgrandchamps F. Clinical relevance of growth factor antagonists in the treatment of benign prostatic hyperplasia. Eur Urol 1997;32:28-31.

(10.) Luchetta G, Weill A, Becker N, et al. Reactivation of the secretion from the prostatic gland in cases of reduced fertility. Biological study of the seminal fluid modifications. Urol Int 1984;39:222-224.

(11.) Barlet A, Albrecht J, Aubert A, et al. Efficacy of Pygeum africanum extract in the medical therapy of urination disorders due to benign prostatic hyperplasia: evaluation of objective and subjective parameters. A placebo controlled double-blind multicenter study. Wien Klin Wochenschr 1990; 102:667-673. [Article in German]

(12.) Chatelain C, Autet W, Brackman F. Comparison of once and twice daily dosage forms of Pygeum africanum extract in patients with benign prostatic hyperplasia: a randomized, double-blind study, with long-term open label extension. Urol 1999;54:473-478.

(13.) Breza J, Dzurny O, Borowka A, et al. Efficacy and acceptability of Tadenan (Pygeum africanum extract) in the treatment of benign prostatic hyperplasia (BPH): a multicentre trial in central Europe. Curr Med Res Opin 1998;14:127-139.

(14.) Carani C, Salvioli V, Scuteri A, et al. Urological and sexual evaluation of treatment of benign prostatic disease using Pygeum africanum at high doses. Arch Ital Urol Nefrol Androl 1991;63:341-345. [Article in Italian]