Thiamine deficiency in congestive heart failure patients receiving long term furosemide therapy

Alternative Medicine Review, March, 2004 by C. Zenuk, J. Healey, J. Donnelly

Zenuk C, Healey, J, Donnelly J, et al. Can J Clin Pharmacol 2003;10:184-188.

OBJECTIVE: To assess the presence of thiamine deficiency in congestive heart failure patients receiving furosemide therapy. DESIGN: Prospective, biochemical analysis of thiamine status was performed in outpatients and inpatients of the University of Ottawa Heart Institute. SUBJECTS: Thirty-two patients with congestive heart failure who received at least 40 mg/day of furosemide were included. Patients were then separated into two groups depending on whether the dose of furosemide was greater than or equal to 80 mg/day. METHODS: The primary measure was actual thiamine status as assessed by the erythrocyte transketolase enzyme activity and the degree of thiamine pyrophosphate effect. RESULTS: Biochemical evidence of severe thiamine deficiency was found in 98% (24 of 25) patients receiving at least 80 mg/day of furosemide and in 57% (four of seven) of patients taking 40 mg Furosemide daily, odds ratio (OR) 19.0 (1.13