Inositol hexaphosphate - Monograph

Alternative Medicine Review, June, 2002

Dosage

Dosage information for humans is limited and the optimal IP6 dosage for cancer treatment is yet to be determined. It is typically dosed at two grams and above daily in divided doses. A study in which IP6 was given to patients at risk for kidney stones utilized doses of 8.8 grams daily. (32)

Warnings and Contraindications

Due to its strong binding affinity for minerals, inositol hexaphosphate should be taken separately from meals, mineral supplements, and multivitamins containing minerals to prevent the potential deficiency that may result.

References

(1.) Graf E. Applications of phytic acid. J Am Oil Chem Soc 1983;60:1861-1867.

(2.) Szwergold BS, Graham RA, Brown TR. Observation of inositol pentakis- and hexakis-phosphates in mammalian tissues by 31P NMR. Biochem Biophys Res Commun 1987;264:874-881.

(3.) Harland BF, Oberleas D. Phytate in foods. Wld Rev Nutr Diet 1987;52:235-259.

(4.) Shamsuddin AM, Vucenik I, Cole KE. IP6: A novel anti-cancer agent. Life Sci 1997;61:343-354.

(5.) Homann MJ, Poole MA, Gaynor PM, et al. Effect of growth phase on phospholipid biosynthesis in Saccharomyces cerevisiae. J Bacteriol 1987;169:533-539.

(6.) Robinson KS, Lai K, Cannon TA, McGraw P. Inositol transport in Saccharomyces cerevisiae is regulated by transcriptional and degradative endocytic mechanisms during the growth cycle that are distinct from inositol-induced regulation. Mol Biol Cell 1996;7:81-89.

(7.) Sakamoto K, Vucenik I, Shamsuddin AM. [3H]-Inositol hexaphosphate is rapidly absorbed and distributed to various tissues in rats. J Nutr 1993;123:861-868.

(8.) Vucenik I, Shamsuddin AM. [3H]-Inositol hexaphosphate (phytic acid) is rapidly absorbed and metabolized by murine and human malignant cells in vitro. J Nutr 1994; 124:861-868.

(9.) Midorikawa K, Murata M, Oikawa S, et al. Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention. Biochem Biophys Res Commun 2001;288:552-557.

(10.) El-Sherbiny YM, Cox MC, Ismail ZA, et al. G0/G1 arrest and S phase inhibition of human cancer cell lines by inositol hexaphosphate (IP6). Anticancer Res 2001;21:2393-2403.

(11.) Shamsuddin AM. Reduction of cell proliferation and enhancement of NK-cell activity. 1992. U.S. Patent #5,082,833.

(12.) Grases F, Costa-Bauza A. Phytate (IP6) is a powerful agent for preventing calcifications in biological fluids: usefulness in renal lithiasis treatment. Anticancer Res 1999;19:3717-3722.

(13.) Reddy BS. Prevention of colon carcinogenesis by components of dietary fiber. Anticancer Res 1999;19:3681-3683.

(14.) Ullah A, Shamsuddin AM. Dose-dependent inhibition of large intestinal cancer by inositol hexaphosphate in F344 rats. Carcinogenesis 1990;11:2219-2222.

(15.) Reddy BS, Hirose Y, Cohen LA, et al. Preventive potential of wheat bran fractions against experimental colon carcinogenesis: implications for human colon cancer prevention. Cancer Res 2000;60:4792-4797.

(16.) Shamsuddin AM, Vucenik I. Mammary tumor inhibition by IP6: A review. Anticancer Res 1999;19:3671-3674.