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Thomson / Gale

Alzheimer's disease a hormone replacement risk factor

AORN Journal,  May, 2004  

The US Food and Drug Administration has asked manufacturers of hormone replacement therapies to include Alzheimer's disease and other forms of dementia on the list of possible risk factors of these medications, according to a Feb 10, 2004, news release from Fisher Center for Alzheimer's Research Foundation at the Rockefeller University, New York. Hormone replacement therapies containing estrogen and progestin are used to treat symptoms of menopause, such as hot flashes and night sweats. It also was hoped that this therapy might help keep memory intact and ward off Alzheimer's disease in older women. A study found, however, that that this treatment does little to prevent Alzheimer's disease and may, in fact, increase the risk.

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Other possible risk factors for women taking these medications include heart disease, stroke, and breast cancer. Risk for developing a serious problem, such as Alzheimer's disease or cancer, appears to be small, however. Experts recommend that women discuss the risks with their physicians and, if they opt to take hormone replacement medications, that they take the lowest possible dose for the shortest possible time.

Hormone Replacement Therapies Carry Alzheimer's Risk (news release, New York: Fisher Center for Alzheimer's Research Foundation, Feb 10, 2003) http://www.alzinfo .org/news/2_17_04.aspx (accessed 27 Feb 2004).

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