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Industry: Email Alert RSS FeedCephalosporin and ciprofloxacin resistance in Salmonella, Taiwan
Emerging Infectious Diseases, June, 2005 by Jing-Jou Yan, Chien-Shun Chiou, Tsai-Ling Yang Lauderdale, Shu-Huei Tsai, Jiunn-Jong Wu
Table 1. Resistance to ciprofloxacin, extended-spectrum
cephalosporins, and both in Salmonella enterica serotypes,
by region and pulsotype, Taiwan, January-May 2004
No. of resistant S. enterica
isolates/no. of total isolates (%)
Resistance and
region * Enteritidis Typhimurium Stanley
Ciprofloxacin 1/161 (0.6) 0/142 (0) 0/53 (0)
resistance
Northern 0/96 (0) 0/38 (0) 0/14 (0)
Central 1/32 (3.1) 0/34 (0) 0/14 (0)
Southern 0/25 (0) 0/60 (0) 0/24 (0)
Eastern 0/8 (0) 0/10 (0) 0/1 (0)
ESC resistance 0/161 (0) 0/142 (0) 3/53 (5.7)
Northern 0/96 (0) 0/38 (0) 1/14 (7.1)
Central 0/32 (0) 0/34 (0) 1/14 (7.1)
Southern 0/25 (0) 0/60 (0) 1/24 (4.2)
Eastern 0/8 (0) 0/10 (0) 0/1 (0)
Ciprofloxacin and 0/161 (0) 0/142 (0) 0/53 (0)
ESC resistance
Northern 0/96 (0) 0/38 (0) 0/14 (0)
Central 0/32 (0) 0/34 (0) 0/14 (0)
Southern 0/25 (0) 0/60 (0) 0/24 (0)
Eastern 0/8 (0) 0/10 (0) 0/1 (0)
No. of resistant S. enterica
isolates/no. of total isolates (%)
Uncommon
Resistance and serotypes All
region * Choleraesuis ([dagger]) serotypes
Ciprofloxacin 38/45 (84.4) 11/199 (5.5) 50/600 (8.3)
resistance
Northern 13/16 (81.3) 6/88 (6.8) 19/252 (7.5)
Central 6/8 (75.0) 4/37 (10.8) 11/125 (8.8)
Southern 18/20 (90.0) 1/65 (1.5) 19/194 (9.8)
Eastern 1/1 (100) 0/9 (0) 1/29 (3.4)
ESC resistance 8/45 (17.8) 9/199 (4.5) 20/600 (3.3)
Northern 1/16 (6.3) 7/88 (8.0) 9/252 (3.6)
Central 0/8 (0) 1/37 (2.7) 2/125 (0.8)
Southern 7/20 (35.0) 1/65 (1.5) 9/194 (4.6)
Eastern 0/1 (0) 0/9 (0) 0/29 (0)
Ciprofloxacin and 8/45 (17.8) 2/199 (1.0) 10/600 (1.7)
ESC resistance
Northern 1/16 (6.3) 1/88 (1.1) 2/252 (0.8)
Central 0/8 (0) 1/37 (2.7) 1/125 (0.8)
Southern 7/20 (35.0) 0/65 (0) 7/194 (3.6)
Eastern 0/1 (0) 0/9 (0) 0/29 (0)
Pulsotypes of
Resistance and Choleraesuis isolates
region * (no of isolates)
Ciprofloxacin
resistance
Northern A (11), D (1), E (1)
Central A (5), C (1)
Southern A (14), B (1), C (1), F (1), G (1)
Eastern A (1)
ESC resistance
Northern
Central
Southern
Eastern
Ciprofloxacin and
ESC resistance
Northern E (1)
Central
Southern A (4), C (1), F (1), G (1)
Eastern
* ESC, extended-spectrum cephalosporin.
([dagger]) Includes 197 isolates of 42 uncommon serotypes and 2
untypeable isolates.
Table 2. Characteristics of 20 Salmonella isolates resistant to
extended-spectrum cephalosporins
gyrA at
position
([dagger])
Specimen Resistance 83 (TCC
Serotype type pl (s) pattern * [Ser])
Albany Urine 9.0 Am ESC Fx Cm Na --
Sxt Tc ([dagger])
Cairo Stool 9.0, 5.4 Am ESC Fx Cm Na TTC (Phe)
Gm Km Sxt Tc
([dagger])
Urine 9.0 Am ESC Fx Cm Cp TTC (Phe)
Na Sxt Tc
Chester Stool 9.0 Am ESC Fx --
Choleraesuis Wound 9.0, 5.4 Am ESC Fx Cm Cp TTC (Phe)
Na Gm Km Sxt Tc
Blood 9.0, 5.4 Am ESC Fx Cm Cp TTC (Phe)
Na Gm Tc
Blood 9.0, 5.4 Am ESC Fx Cm Cp TTC (Phe)
Na Gm Km Sxt Tc
Blood 9.0, 5.4 Am ESC Fx Cm Cp TTC (Phe)
Na Gm Km Sxt
Joint 9.0, 5.4 Am ESC Fx Cm Cp TTC (Phe)
fluid Na Gm Km Sxt Tc
Kaduna Tissue 9.0, 5.4 Am ESC Fx Cm Cp TTC (Phe)
Na Sxt Tc
Saintpaul Stool 9.0 Am ESC Fx Gm --
Stanley Stool 9.0, 5.4 Am ESC Fx --
Cm Sxt Tc
Stool 9.0 Am ESC Fx --
Cm Sxt Tc
gyrA at
position
([dagger])
Isolate
(restriction
parC at pattern of
position 80 transferred
(AGC [Ser]) [bla.sub.CMY-2]
Specimen 87 (GAC ([double plasmid)
Serotype type [Asp]) dagger]) ([section])
Albany Urine AAC (Asn) -- SA04.028 (C)
Cairo Stool -- -- NC04.001 (H1),
NC04.002 (H1),
NC04.003 (H1)
Urine GGC (Gly) AAC (Arg) NC04.004 (H2)
Chester Stool -- -- NG04.016 (G)
Choleraesuis Wound AAC (Asn) ATC (Ile) NL04.050 (B)
Blood AAC (Asn) ATC (Ile) SB04.003 (A)
Blood AAC (Asn) ATC (Ile) SE04.005 (F),
SG04.060
Blood AAC (Asn) ATC (Ile) SG04.039 (E1),
SG04.086
Joint AAC (Asn) ATC (Ile) SG04.042 (E2),
fluid SG04.047 (E4)
Kaduna Tissue AAC (Asn) ATC (Ile) CE04.015 (I)
Saintpaul Stool -- -- NG04.011 (G),
NG04.018 (G)
Stanley Stool -- -- CG04.039 (D)
Stool -- -- NB04.022 (A),
SE04.006 (E3)
* Am, ampicillin; ESC, extended-spectrum cephalosporins, Fx,
cefoxitin, Cm, chloramphenicol, Cp, ciprofloxacin; Na, nalidixic acid;
Gm, gentamicin, Km, kanamycin, Sxt, trimethoprim-sulfamethoxazole; Tc,
tetracycline.
([dagger]) The S. Albany isolate and the 3 S. Cairo isolates showed
decreased susceptibilities to ciprofloxacin (MIC 0.25-1 [micro]g/mL).
([double dagger]) Nucleotide and amino acid changes at the QRDRs of
gyrA and parC. --, no alterations in the genes.
([section]) For each isolate, the first letter indicates region (C,
central region; N, northern region, S, southern region), and the
second letter represents hospital. Isolates NC04.001, NC04.002, and
NC04.003 were from the same patients; all other isolates were from
different patients.
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