The enzyme of enzymes - Nattokinase

Townsend Letter for Doctors and Patients, Nov, 2002 by Nicholas Dr. Calvino

Conclusion

Nattokinase appears to have the added benefit of significantly reducing elevated blood pressure (an often concomitant condition in cardiovascular disease risk factors, such as high fibrin). Nattokinase appears to be safe, and has been used for over 1,000 years safely with no reports of toxicity. Various other nutritional supplements/herbs have been reported to have fibrinolytic activity, however, the potency of Nattokinase appears to be superior (see table 1.3). Furthermore, Nattokinase also appears to be an activator of various other metabolic enzymes and vitamins, cleaving them from their inactive to their active forms. The strength and magnitude of this direct support for the metabolic enzymes of the body, from an oral enzyme supplement, is unique to Nattokinase and shows great promise as a nutritional supportive agent in exciting and diverse ways. The potent fibrinolytic enzyme Nattokinase appears to be safe based upon the long-term traditional use of this food. Nattokinase has many benefits including con venience of oral administration, confirmed efficacy, prolonged effects, cost effectiveness, and it can be used preventively. It is a naturally occurring, food based dietary supplement, being marketed in this country by innovative nutriceutical companies and has demonstrated stability in the gastrointestinal tract, as well as to changes in pH and temperature. Truly, Nattokinase represents a quantum leap forward in the future of enzymology and a new chapter in dietary supplements.

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Table 1.2

Various Health Conditions Reported to be Associated with or Aggravated
by High Fibrin Levels:
Angina
Venous stasis, thrombosis, emboli
Cardiovascular disease / Stroke
Atherosclerosis
Fibromyalgia / Chronic Fatigue
Claudication
Retinal Pathology
Hemorrhoids / Varicose Veins
Soft Tissue Rheumatisms
Muscle Spasm
Poor Healing
Chronic Inflammation and Pain
Peripheral Vascular Disease
Hypertension
Tissue Oxygen Deprivation
Infertility
Gynecology conditions (e.g. endometriosis, uterine fibroids)

References

Allergy Research Group Nutraceuticals, Clinical Focus Newsletter, August 2002. www.allergyresearchgruoup.com

Abe, T. Et al. Clinical effect of urokinase (60,000 unit/day) on cerebral infarction: Comparative study by means of multiple center double blind test. Blood and Vessels 12:342-358, 1981.

Abe, T. Kazama, M. Kinoshita, T. Naito, I. Ogushi, T. Yoshimura, Y. Teruya. J. Shimizu, N. Shift of fibrinolysis system at oral administration of urokinase in human subjects: Double blind cross over study. Blood and Vessels 13:472-479, 1982.

Astrup, T. and Egeblad, K. (1965). Thromboelastographic patterns produced by fibrinolytic agents incorporated in fibrin. Am. J. Physiol., 209, 84-94.

Berg, D. Berg, L. Couvaras, J. Harrison, H. Chronic Fatigue Syndrome and/or Fibromyalgia as a Variation of Antiphospholipid Antibody Syndrome: an Explanatory Model and Approach to Laboratory Diagnosis. Blood Coag Fibrinol 10:435-'38, 1999.

Harenberg J, Giese C, Zimmermann R, Effect of dried garlic on blood coagulation, fibrinolysis, platelet aggregation and serum cholesterol levels in patients with hyperlipoproteinemia, Atherosclerosis 1988, Dec;74(3):247-9.