Illegal? Who would have thought a compound developed to help people overcome muscle atrophy would become the bodybuilding breakthrough of the decade?

Flex, July, 2005

DSG-122702135

Endothil[TM]-CR

Musculogenic Cell Recruiter[TM]

[6mcg Functional Material]

Endothil[TM]-CR Helps Build Muscle Mass and Strength in Exercising Adult Men

INTRODUCTION

It is well known that increased muscle mass and strength occur in the most effective manner when exercise routines are done to exhaustion, i.e, when exercise results in ischemia or hypoxia in localized areas of muscle. Hypoxia produces the "signals" required to boost muscle repair and growth in the area of strain. One of the goals of weight training is to build muscle without scar tissue. Too much exertion can tear muscle to the point where scarring will result. Too little exercise produces little increase in mass or strength. There appears to be an optimal point for maximal growth without scarring. Hence, currently the attempt to increase muscle mass and strength through exercise is constrained by these considerations.

As research begins to unravel the mechanisms involved in building muscle mass, it has become apparent that it should be possible to enhance muscle growth by stimulating certain aspects of the muscle building process. For example, we know that ischemia or hypoxia, with attendant inflammation and activation of so-called growth factors, produces signals that recruit the migration of progenitor cells from the bone marrow and blood stream to the hypoxic area to be used in rebuilding the muscle. The discovery of a method for enhancing the recruitment of the progenitor cells might increase the incorporation of these progenitor cells into the matrix of new muscle tissue, contributing to an increased muscle mass.

One of the crucial points in the muscle rebuilding process following exercise trauma may be the activation of receptors located on the muscle cells as well as on cells of the microvasculature in the muscle tissue. The most important of these receptors is the a7-nar (alpha-7-nicotinic acetylcholine receptor). Stimulation of this receptor initiates the cascade of events that eventually results in the repair of muscle and growth of new muscle. Repeated stimulation of the a7-nar actually results in the up-regulation of this receptor such that the efficiency of the system is improved and ever greater muscle growth becomes a distinct possibility. The localized nature of this process must be emphasized. Hypoxia is the localized environment that signals progenitor cells to migrate toward the site of muscle exertion. Thus, by isolating a muscle group in the right leg and exercising it using a specific exercise, you create an hypoxic zone in that area, so to speak, and you would expect only that leg muscle to benefit. This is good in that it allows you to work on specific areas of the body in a systematic manner.

Recently, a compound has been discovered that contains a naturally occurring active molecule known to activate the a7-nar. This molecule is the core substance in Endothil[TM]-CR (ECR). It is theorized that, based on its ability to interact with a7-nars, the active molecule in ECR should stimulate the migration of progenitor cells from bone marrow and blood stream in much the same way that exercising to exhaustion does. If this is in fact the case we predict that the combination of exercise and the consumption of ECR will produce even greater muscle growth and increments in strength than either agent used alone.