Brittle nails: pathogenesis and treatment

Journal of Drugs in Dermatology, Jan, 2003 by Hendrik Uyttendaele, Adam Geyer, Richard K. Scher

In summary, the syndrome of brittle nails may be more than a cosmetic problem. The frayed and fragile nail plate tends to catch on everything and therefore does impact on function, particularly of the fingernails.

References

(1.) Lubach D, Cohrs W, Wurzinger, R. Incidence of brittle nails. Dermatologica 1986; 172:144-7.

(2.) Tosti A, Piraccini BM. Treatment of common nail disorders. Dermatol Clin 2000; 18:339-48.

(3.) Baran R. Fragilite des ongles. Cutis (France) 1978; 2:457.

(4.) Scher RK, Bodian AB. Brittle nails. Semin Dermatol 1991 10:21-5.

(5.) Scher RK. Brittle nails. Int J Dermatol 1989; 28:515-6.

(6.) Von Fisher F. Acanthosis Nigricans. Dermatologica 1949; 98:319-20.

(7.) Keipert JA, Kelly R. Acquired juvenile hypothyroidism presenting with nail changes. Australas J Dermatol 1978; 19:89-90.

(8.) Mullin GE, Eastern JS. Cutaneous consequences of accelerated thyroid function. Cutis 1986; 37:109-14.

(9.) Yuzuk S, Keren G, Lobel D, Kahana M, Schewach-Millet M. Primary cutaneous manifestation in a child with idiopathic hypoparathyroidism. Int J Dermatol 1986; 25:531-2.

(10.) Wit JM, Beemer FA, Barth PG, Oorthuys JW, Dijkstra PF, Van den Brande JL, Leschot NJ. Cerebral gigantism (Sotos syndrome). Compiled data of 22 cases. Analysis of clinical features, growth and plasma somatomedin. Eur J Pediatr 1985; 144:131-40.

(11.) Djaldetti M, Fishman P, Hart J. The iron content of finger-nails. in iron deficient patients. Clin Sci (Lond) 1987; 72:669-72.

(12.) Chevrant-Breton J, Simon M, Bourel M, Ferrand B. Cutaneous manifestations of idiopathic hermochromatosis. Study of 100 cases. Arch Dermatol 1977; 113:161-5.

(13.) Chao SC, Lee JY. Brittle nails and dyspareunia as first clues to recurrences of malignant glucagonoma. Br J Dermatol 2002; 146:1071-4.

(14.) Runne U, Orfanos CE. The human nail: structure, growth and pathological changes. Curt Probl Dermatol 1981; 9:102-49.

(15.) Brazin SA, Johnson WT, Abramson LJ. The acrodermatitis enteropathica-like syndrome. Arch Dermatol 1979; 115:597-9.

(16.) Finlay AY, Frost P, Keith AD, Snipes W. An assessment of factors influencing flexibility of human fingernails. Br J Dermatol 1980; 103:357-65.

(17.) Brehm G. Therapie der onychorrhexis. Dtsch Med Wochenschr 1987; 112:980.

(18.) Lubach D, Wurzinger, R. Trace elements in samples of brittle and nonbrittle finger nails. Derm Beruf Umwelt 1986; 34:37-9.

(19.) Zaun H. Bruchige Fingernagel. Dtsch Med Wochenschr 1987; 112:198-9.

(20.) Campbell AJ, McEwan GC. Treatment of brittle nails and dry eyes. Br J Dermatol 1981; 105:113.

(21.) Colombo VE, Gerber F, Bronhofer M, Floersheim GL. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy. J Am Acad Dermatol 1990; 23:1127-32.

(22.) Floersheim GL. [Treatment of brittle fingernails with biotin]. Z Hautkr 1989; 64:41-8.

(23.) Hochman LG, Scher RK, Meyerson MS. Brittle nails: response to daily biotin supplementation. Cutis 1993; 51:303-5.

(24.) Comben N, Clark RJ, Sutherland DJ. Clinical observations on the response of equine hoof defects to dietary supplementation with biotin. Vet Rec 1984; 115:642-5.