Pharma Industry
Industry: Email Alert RSS FeedSystemic and topical drugs for aging skin
Journal of Drugs in Dermatology, August, 2003 by Michael Kockaert, Martino Neumann
Conclusion
Slowing or reversing the symptoms of aging skin is an increasingly common reason for a patient to consult a dermatologist. Most patients hold out hope that the aging process can be reversed with miraculous topical agents. While there is no 'magic formula', topical treatment in conjunction with adequate use of sunscreens with broad-spectrum activity against both UVB and UVA can significantly reduce and prevent the symptoms of photoaging, and even improve skin lesions with histologic atypia. Combined treatments offer the best results, but therapies should be tailored to each patient based on their individual skin qualities and degree of photodamage.
References
Most RecentPharma Articles
- BioPure Exec Sentenced to Three Years for Faking Cancer to Avoid SEC Probe
- Novartis Sought Ban on Bunny Costumes at Protests
- As Tax Breaks for Pfizer End, Jobs Disappear
- Merck Statement on Zetia Mess Is a Masterpiece of Spin
- Will Plavix Competitor Cangrelor Be a Prince Rather than a Frog for The...
- More »
(1). Gendler EC. Topical treatment of the aging face. Dermatol Clinics 1997; 4:561-567.
(2.) Futoryan T, Gilchrest BA. Retinoids and the skin. Nutrition Reviews 1994; 52:299-310.
(3.) Liebert MA. Final report on the safety assessment of retinyl palmitate and retinol. J Am Coll of Toxicol 1987; 6:279-320.
(4.) Verschoore M, Bouclier M, Czernielewski J et al. Topical retinoids. Their uses in dermatology. Dermatol Clinics 1993; 1:107-15.
(5.) Orfanos CE, Zouboulis CC, Almond-Roesler B et al. Current use and future potential role of retinoids in dermatology. Drugs 1997; 53:358-88.
(6.) Saurat JH, Didierjean I, Masgrau E. Topical retinaldehyde on human skin: biologic effects and tolerance. J Invest Dermatol 1994; 103:770-4.
(7.) Gilchrest BA. Treatment of photodamage with topical tretinoin: an overview. J Am Acad Dermatol 1997; 36:Supl.27-36.
(8.) Kang S, Fischer GJ, Voorhees JJ. Photoaging and topical tretinoin, therapy, pathogenesis and prevention. Arch Dermatol 1997; 133:1280-4.
(9.) Fischer GJ, Datta SC, Talwar HS et al. Molecular basis of sun-induced premature skin aging and retinoid antagonism. Nature 1996; 379:335-9.
(10.) Kligman A. Topical treatments for photoaged skin. Postgrad. Medicine 1997; 102:115-26.
(11.) Kligman A. Topical retinoic acid(tretinoin) for photoaging: conceptions and misperceptions. Cutis 1996; 57:142-4.
(12.) Duell E, Derguini F, Kang S. Extraction of human epidermis treated with retinol yields retro retinoids in addition to free retinol and retinyl esters. J Invest Dermatol 1996; 107:178-82.
(13.) Kretz A. Vitamin A als kosmetischer Wirksfoff. Parfumerie und Kosmetik 1994; 10:662-4.
(14.) Glaser DA, Rogers C. Topical and systemic therapies for the aging face. Facial Plastic Surgery Clinics of North America 2001; 9(2):189-96.
(15.) Wolf R, Wolf D, Ruocco V. Vitamin E: the radical protector. J Eur Acad Dermatol Venereol 1998; 10:103-17.
(16.) Jurkiewicz BA, Bisset DL, Buettner GR. Effect of topically applied tocoferol on ultraviolet radiation-mediated free radical damage in skin. J Invest Dermatol 1995; 104:484-8.
(17.) Griffits CEM, Drug treatment of photoaged skin. Drugs and Aging 1999; 14:289-99.
(18.) Colven RM, Pinnell SR. Topical vitamin C in aging. Clinics in Dermatology 1996; 14:227-34.
(19.) Nakamura T, Pinell SR, Darr D et al. Vitamin C abrogates the deleterious effects of UVB radiation on cutaneous immunity by a mechanism that does not depend on TNF-x. J Invest Dermatol 1997; 109(1):20-24.
- How to choose the right insurance carrier for your business
- Real Estate: Prepare your properties to weather what lies ahead
- Technology: Be prepared if part of your global supply chain goes missing
Most Recent Health Articles
Most Recent Health Publications
Most Popular Health Articles
- 50 home remedies that work: these safe, fast, and effective fixes will relieve what ails you - Cover Story
- Detox in 7 days: a detoux diet can help you shed up to 10 pounds and leave you feeling terrific. Our weeklong plan shows you how to lose the weight and keep it off - Cover story
- All about nightshades: explore the hidden hazards of your favorite food with macrobiotic nutritionist Lino Stanchich
- Treat sinusitis naturally: breath easy and relieve sinus pressure with these remedies - Quick Fixes and Long-Term Solutions
- La anemia falciforme - causas y tratamiento



