Measles virus nucleoprotein

SciTech Book News, June, 2008

Measles virus nucleoprotein.

Ed. by Sonia Longhi.

Nova Biomedical Books

2007

163 pages

$79.00

Hardcover

Intrinsically disordered proteins

QR201

Longhi (biological macromolecules, UMR 6098 CNRS, University Aix- Marseille I and II, Luminy Campus, France) collects recent research from France, the UK, and the US on the measles virus nucleoprotein. The book focuses on the main structural information available on the nucleoprotein, showing that it consists of a structured core (NCORE) and an intrinsically disordered C-terminal domain (NTAIL). The functional implications of the disordered nature of NTAIL are discussed in light of the ability of disordered regions to establish interactions with multiple partners, thus leading to multiple biological effects. The book consists of five chapters. Two chapters are devoted to the general functions of the nucleoprotein in transcription and replication and to a detailed overview of its structural properties. The remaining three chapters focus on the functional relevance of the interaction between NTAIL and its various intracellular and extracellular partners. B&w and color images are included.

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