Clinical bioinformatics

SciTech Book News, June, 2008

Clinical bioinformatics.

Ed. by Ronald J.A. Trent.

Humana Press Inc.

2008

382 pages

$99.50

Hardcover

Methods in molecular medicine.

R853

The contributors of these 19 papers describe software applications they use in clinical settings or in clinically-based projects and offer case studies and advice from the front lines. Their topics include in silico gene discovery, a whole genome-wide association study using a two-stage sequential selection methods, single nucleotide polymorphism tagging, measurement of the effects of genes and environments on complex traits, computer-assisted reading of DNA sequences, evaluation of DNA sequence variants of unknown biological significance, DNA variant databases, protein comparative sequence analysis and computer modeling, microbial protein characterization using peptide-mass fingerprinting, two-dimensional gel electrophoresis for discovery proteomics, decision support systems in clinical bioinformatics, and e-consulting. Papers on microarray experiments include using microarrays in cancer research, to identify molecular portraits, to analyze signaling pathways, and to study viral gene expression, and others give web and online resources.

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