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Chemists working at the University of North Carolina at Chapel Hill have developed a new way to detect tiny genetic mutations responsible for conditions such as cystic fibrosis and cancer. Chemistry professor Dr. Holden Thorp, a founder of Xanthon Inc. of Research Triangle Park, and Dr. Patricia Ropp, a postdoctoral research associate, developed the method, which uses inexpensive electronic equipment.

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The method measures different electrical currents generated when guanine is paired with its correct DNA chemical partner versus an incorrect chemical marker. Future advances in the method may one day lead to a device that can be used to do routine analysis, Thorp said.

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