No mercy for MRSA: treatment alternatives to vancomycin and linezolid

Medical Laboratory Observer, Jan, 2005 by Dennis L. Wegner

References

1. Fukatsu K, Saito H, Matsuda T, Ikeda S, Furukawa S, Muto T. Influences of type and duration of antimicrobial prophylaxis on an outbreak of methicillin-resistant Staphylococcus aureus and on the incidence of wound infection. Arch Surg. December 1997;132:1320-1325.

2. Weber SG, Gold HS, Hooper DC, Karchmer AW, Carmeli Y. Fluoroquinolones and the risk for methicillin-resistant Staphylococcus aureus in hospitalized patients. Emerg Infect Dis. November 2003;9:1415-1422.

3. Sakoulas G, Moise-Broder PA, Schentag J, Forrest A, Moellering RC Jr, Eliopoulos GM. Relationship of MIC and bactericidal activity to efficacy of vancomycin for treatment of methicillin-resistant Staphylococcus aureus bacteremia. J Clin Microbiol. June 2004;42:2398-2402.

4. Moise PA, Schentag JJ. Vancomycin treatment failures in Staphylococcus aureus lower respiratory tract infections. Int J Antimicrob Agents. November 2000;16 Suppl 1:S31-S34.

5. Gang RK, Sanyal SC, Mokaddas E, Lari AR. Rifampicin as an adjunct to vancomycin therapy in MRSA septicaemia in burns. Burns. 1999;25:640-644.

6. Burnie J, Matthews R, Jiman-Fatami A, Gottardello P, Hodgetts S, D'arcy S. Analysis of 42 cases of septicemia caused by an epidemic strain of methicillin-resistant Staphylococcus aureus: evidence of resistance to vancomycin. Clin Infect Dis. 2000;31:684-689.

7. Iyer S, Jones DH. Community-acquired methicillin-resistant Staphylococcus aureus skin infection: a retrospective analysis of clinical presentation and treatment of a local outbreak. J Am Acad Dermatol. June 2004;50(6):854-858.

8. Walsh TJ, Standiford HC, Reboli AC, et al. Randomized double-blinded trial of rifampin with either novobiocin or trimethoprim-sulfamethoxazole against methicillin-resistant Staphylococcus aureus colonization: prevention of antimicrobial resistance and effect of host factors on outcome. Antimicrob Agents Chemother. June 1993;37(6):1334-1342.

9. Clumeck N, Marcelis L, Amiri-Lamraski MH, Gordts B. Treatment of severe staphylococcal infections with a rifampicin-minocycline association. J Antimicrob Chemother. June 1984; Suppl C:17-22.

10. Darouiche R, Wright C, Hamill R, Koza M, Lewis D, Markowski J. Eradication of colonization by methicillin-resistant Staphylococcus aureus by using oral minocycline-rifampin and topical mupirocin. Antimicrob Agents Chemother. August 1991;35(8):1612-1615.

11. Smith SM, Eng RHK, Tecson-Tumang F. Ciprofloxacin therapy for methicillin-resistant Staphylococcus aureus infections or colonizations. Antimicrob Agents Chemother. February 1989;33(2):181-184.

By Dennis L. Wegner, PhD

Dennis L. Wegner, PhD, is the consulting clinical microbiologist for a pathology group that provides laboratory services to eight community hospitals in southeast Iowa. On invitation, he presents his "Clinically Relevant, Cost-Effective Community-Hospital Microbiology" traveling workshop throughout the United States. He can be reached at dwegner@orhc.com.

Disclaimer: This article is intended solely as a literature review. The author and his employers do not wish to imply that recommendations are being made for treatment of staphylococcal infection in any patient and assume no legal liability for any treatment outcomes. Rather, it is hoped that the material contained in the article will prompt discussions between laboratorians, physicians, and pharmacists that will result in improved patient care. It is also hoped that the resultant decreased use of vancomycin will lessen the chances of selecting for vancomycin-resistant staphylococci and enterococci.

COPYRIGHT 2005 Nelson Publishing
COPYRIGHT 2008 Gale, Cengage Learning

 

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