Potentially inappropriate medication prescriptions among elderly nursing home residents: their scope and associated resident and facility characteristics

Health Services Research, Oct, 2004 by Denys T. Lau, Judith D. Kasper, D.E.B. Potter, Alan Lyles

Table 1: Patterns of Potentially Inappropriate Medication Prescriptions
(PIRx) among Residents, Aged 65 and Older, with a Nursing Home Stay of
Three Consecutive Months or Longer in 1996. ([section])

Patterns of PIRx                           % of Residents (S.E.)

Number of PIRx ([paragraph])
  Zero (no PIRx)                                49.7 (1.04)
  At least one                                  50.3 (1.04)
  One                                           28.1 (0.89)
  Two                                           13.3 (0.73)
  Three                                          5.3 (0.40)
  Four or more                                   3.6 (0.33)
Type of PIRx (#)
  Inappropriate drug choice                     40.4 (1.04)
  Excess dosage                                 11.4 (0.61)
  Drug-disease interaction                      12.8 (0.64)
PIRx with the potential for severe harm         17.3 (0.81)

([section]) 51% of all nursing home users in 1996 (n = 3,372).
Percentages based on weighted data and available prescribed medicine
data.

([paragraph]) Number of PIRx indicates the number of different drugs
names that matched Beers's criteria received during the year and not
the frequency of use.

(#) Residents can have multiple types of PIRx exposures during the
year.

Source: Center for Cost and Financing Studies, Agency for Healthcare
Research and Quality, The 1996 Medical Expenditure Panel Survey Nursing
Home Component.

Table 2: Characteristics of Nursing Home Residents and Multivariate
Logistic Regression Analysis of Resident and Resident/Facility
Characteristics Associated with Having Potentially Inappropriate
Medication Prescriptions (PIRx). ([section])

                                                      Resident
                                                       Model

                                 % of      Odds            95%
Characteristics                Residents   Ratio           C.I.

Resident Characteristics
  Age
    65-74                        14.6      1.00    (0.81, 1.34)
    75-84                        35.8      1.04    (0.74, 1.06)
    85 and older                 49.6      0.89    (1.00, 1.00)
  Sex
    Male                         26.2      1.16    (0.96, 1.40)
    Female                       73.8      1.00    (1.00, 1.00)
  Race
    Black                         8.1      0.79    (0.60, 1.05)
    White/Hispanics/             91.9      1.00    (1.00, 1.00)
      others
  Marital status
    Married                      17.9      1.10    (0.87, 1.38)
    Not married                  82.1      1.00    (1.00, 1.00)
  Living children
    Yes                          70.6      1.02    (0.86, 1.22)
    No                           29.4      1.00    (1.00, 1.00)
  Education level
    No high school degree        54.6      1.02    (0.85, 1.22)
    With high school             45.4      1.00    (1.00, 1.00)
      degree
  Poverty level
    Less than poverty            26.2      1.06    (0.71, 1.57)
    100 to <200 percent          45.6      0.88    (0.61, 1.27)
    200 to <400 percent          20.9      0.89    (0.60, 1.31)
    400 percent or more           7.3      1.00    (1.00, 1.00)
  Medicaid coverage
    Yes                          71.3      1.39    (1.10, 1.75) *
    No                           28.7      1.00    (1.00, 1.00)
  Admission before 1996
    Yes                          77.5      1.06    (0.82, 1.39)
    No                           22.5      1.00    (1.00, 1.00)
  Nursing home days in 1996
    90 to 120 days                4.9      0.87    (0.56, 1.34)
    121 to 200 days              11.4      0.87    (0.64, 1.17)
    201 to 280 days              11.6      1.04    (0.75, 1.43)
    281 to 366 days              72.1      1.00    (1.00, 1.00)
  Mental status
    Alzheimer's disease          47.7      0.88    (0.72, 1.06)

      and other dementia
    Other mental                 15.1      1.35    (1.04, 1.76) *
      disorders only
    No mental disorder           37.2      1.00    (1.00, 1.00)
  Number of activities-of-
    daily-living limitations
      0 to 3                     23.5      1.05    (0.84, 1.32)
      4 to 5                     30.3      1.14    (0.99, 1.40) ([yen])
      6                          46.2      1.00    (1.00, 1.00)
  Behavior problems
      Yes                        27.7      1.16    (0.98, 1.39) ([yen])
      No                         72.3      1.00    (1.00, 1.00)
  Communication problems
      Yes                        29.7      0.66    (0.55, 0.80) **
      No                         70.3      1.00    (1.00, 1.00)
  Average number of drugs
    per month
      Less than 5                31.6      0.25    (0.19, 0.31) **
      5 to <9                    44.4      0.49    (0.39, 0.62) **
      9 or more                  24.0      1.00    (1.00, 1.00)
Facility Characteristics
  Ownership
      For-profit                 64.6
      Nonprofit/Public           35.4
  Type
      Hospital-based              7.0
      With multiple              12.6
        levels of care
      With only NH beds          80.4
  Certification status
      Not federally               3.3
        certified
      Either Medicare            16.2
        only or Medicaid
        only
      Medicare and               80.5
        Medicaid
  Accreditation status
      Yes                        16.6
      No                         83.4
  Number of beds
      3 to 49                     6.0
      50 to 99                   25.1
      100 to 149                 33.9
      150 to 199                 15.7
      200 or more                19.3
  Registered nurse (RN)-to-
    non-RN ratio
      Fewer than 1 : 10          32.6
      Between 1 : 10 and         38.5
        1 : 5
      Greater than 1 : 5         28.9
  Registered nurse
      (RN)-to-resident ratio
      Fewer than 1 : 20          26.0
      Between 1 : 20 and         42.8
        1 : 10
      Greater than 1 : 10        31.2
  Pharmacist onsite once
    a week
      Yes                        46.2
      No                         53.8
  Psychologist or
    psychiatrist onsite
      once a week
      Yes                        41.3
      No                         58.7
  Selected technological
    services offered
    ([paragraph])
      3 or 4 services            13.7
      2 services                 44.4
      1 service                  32.5
      None                        9.4
  Influenza vaccination
    percentage
      90 percent and             51.5
        higher
      75 percent to < 90         27.4
        percent
      Less than 75               21.1
        percent
  Census region
      Northeast                  23.4
      Midwest                    31.8
      South                      32.8
      West                       12.0
  Metropolitan statistical
    area
      Yes                        70.1
      No                         29.9
  Nursing home beds
    available (#)
      5 and fewer                15.2
      > 5 to 10                  25.5
      > 10 to 15                 22.9
      > 15 to 20                 12.5
      More than 20               23.9
  County-level income
    per capita (in $1,000s)
      Less than or equal         30.2
        20
      > 20 to 25                 34.8
      > 25 to 30                 23.5
      More than 30               11.5

                                          Facility
                                           Model

                               Odds            95%
Characteristics                Ratio           C.I.

Resident Characteristics
  Age
    65-74
    75-84
    85 and older
  Sex
    Male
    Female
  Race
    Black
    White/Hispanics/
      others
  Marital status
    Married
    Not married
  Living children
    Yes
    No
  Education level
    No high school degree
    With high school
      degree
  Poverty level
    Less than poverty
    100 to <200 percent
    200 to <400 percent
    400 percent or more
  Medicaid coverage
    Yes
    No
  Admission before 1996
    Yes
    No
  Nursing home days in 1996
    90 to 120 days
    121 to 200 days
    201 to 280 days
    281 to 366 days
  Mental status
    Alzheimer's disease
      and other dementia
    Other mental
      disorders only
    No mental disorder
  Number of activities-of-
    daily-living limitations
      0 to 3
      4 to 5
      6
  Behavior problems
      Yes
      No
  Communication problems
      Yes
      No
  Average number of drugs
    per month
      Less than 5
      5 to <9
      9 or more
Facility Characteristics
  Ownership
      For-profit                1.04   (0.86, 1.25)
      Nonprofit/Public          1.00   (1.00, 1.00)
  Type
      Hospital-based            0.86   (0.55, 1.35)
      With multiple             0.94   (0.75, 1.19)
        levels of care
      With only NH beds         1.00   (1.00, 1.00)
  Certification status
      Not federally             2.54   (0.34, 18.89)
        certified
      Either Medicare           0.88   (0.69, 1.14)
        only or Medicaid
        only
      Medicare and              1.00   (1.00, 1.00)
        Medicaid
  Accreditation status
      Yes                       0.78   (0.61, 0.99) *
      No                        1.00   (1.00, 1.00)
  Number of beds
      3 to 49                   0.66   (0.41, 1.05) ([yen])
      50 to 99                  0.88   (0.68, 1.13)
      100 to 149                0.93   (0.73, 1.18)
      150 to 199                1.03   (0.78, 1.37)
      200 or more               1.00   (1.00, 1.00)
  Registered nurse (RN)-to-
    non-RN ratio
      Fewer than 1 : 10
      Between 1 : 10 and
        1 : 5
      Greater than 1 : 5
  Registered nurse
      (RN)-to-resident ratio
      Fewer than 1 : 20         1.37   (1.06, 1.75) *
      Between 1 : 20 and        1.09   (0.90, 1.31)
        1 : 10
      Greater than 1 : 10       1.00   (1.00, 1.00)
  Pharmacist onsite once
    a week
      Yes                       0.96   (0.81, 1.14)
      No                        1.00   (1.00, 1.00)
  Psychologist or
    psychiatrist onsite
      once a week
      Yes                       0.97   (0.81, 1.15)
      No                        1.00   (1.00, 1.00)
  Selected technological
    services offered
    ([paragraph])
      3 or 4 services           0.95   (0.72, 1.25)
      2 services                1.08   (0.81, 1.44)
      1 service                 0.95   (0.67, 1.34)
      None                      1.00   (1.00, 1.00)
  Influenza vaccination
    percentage
      90 percent and            1.19   (0.97, 1.46)
        higher
      75 percent to < 90        1.18   (0.95, 1.48)
        percent
      Less than 75              1.00   (1.00, 1.00)
        percent
  Census region
      Northeast                 1.20   (0.88, 1.63)
      Midwest                   1.23   (0.92, 1.64)
      South                     1.18   (0.88, 1.57)
      West                      1.00   (1.00, 1.00)
  Metropolitan statistical
    area
      Yes                       0.77   (0.62, 0.96) *
      No                        1.00   (1.00, 1.00)
  Nursing home beds
    available (#)
      5 and fewer               0.85   (0.65, 1.11)
      > 5 to 10                 1.03   (0.81, 1.32)
      > 10 to 15                1.05   (0.83, 1.33)
      > 15 to 20                1.06   (0.81, 1.38)
      More than 20              1.00   (1.00, 1.00)
  County-level income
    per capita (in $1,000s)
      Less than or equal        1.27   (0.90, 1.80)
        20
      > 20 to 25                1.33   (0.98, 1.79) ([yen])
      > 25 to 30                1.51   (1.11, 2.05) *
      More than 30              1.00   (1.00, 1.00)

                                         Resident/
                                       facility Model

                               Odds            95%
Characteristics                Ratio           C.I.

Resident Characteristics
  Age
    65-74                       1.07   (0.83, 1.38)
    75-84                       0.93   (0.78, 1.11)
    85 and older                1.00   (1.00, 1.00)
  Sex
    Male                        1.14   (0.95, 1.37)
    Female                      1.00   (1.00, 1.00)
  Race
    Black                       0.78   (0.59, 1.04) ([yen])
    White/Hispanics/            1.00   (1.00, 1.00)
      others
  Marital status
    Married
    Not married
  Living children
    Yes
    No
  Education level
    No high school degree
    With high school
      degree
  Poverty level
    Less than poverty
    100 to <200 percent
    200 to <400 percent
    400 percent or more
  Medicaid coverage
    Yes                         1.31   (1.09, 1.59) *
    No                          1.00   (1.00, 1.00)
  Admission before 1996
    Yes                         0.99   (0.79, 1.24)
    No                          1.00   (1.00, 1.00)
  Nursing home days in 1996
    90 to 120 days              0.84   (0.56, 1.25)
    121 to 200 days             0.86   (0.65, 1.13)
    201 to 280 days             0.98   (0.74, 1.31)
    281 to 366 days             1.00   (1.00, 1.00)
  Mental status
    Alzheimer's disease         0.86   (0.71, 1.03)
      and other dementia
    Other mental                1.40   (1.07, 1.82) *
      disorders only
    No mental disorder          1.00   (1.00, 1.00)
  Number of activities-of-
    daily-living limitations
      0 to 3                    1.07   (0.85, 1.35)
      4 to 5                    1.23   (1.01, 1.49) *
      6                         1.00   (1.00, 1.00)
  Behavior problems
      Yes                       1.17   (0.98, 1.41) ([yen])
      No                        1.00   (1.00, 1.00)
  Communication problems
      Yes                       0.69   (0.57, 0.84) **
      No                        1.00   (1.00, 1.00)
  Average number of drugs
    per month
      Less than 5               0.23   (0.19, 0.29) **
      5 to <9                   0.46   (0.37, 0.56) **
      9 or more                 1.00   (1.00, 1.00)
Facility Characteristics
  Ownership
      For-profit
      Nonprofit/Public
  Type
      Hospital-based
      With multiple
        levels of care
      With only NH beds
  Certification status
      Not federally
        certified
      Either Medicare
        only or Medicaid
        only
      Medicare and
        Medicaid
  Accreditation status
      Yes                       0.70   (0.54, 0.92) *
      No                        1.00   (1.00, 1.00)
  Number of beds
      3 to 49                   0.55   (0.34, 0.90) *
      50 to 99                  0.80   (0.62, 1.03) ([yen])
      100 to 149                0.92   (0.73, 1.17)
      150 to 199                0.99   (0.74, 1.31)
      200 or more               1.00   (1.00, 1.00)
  Registered nurse (RN)-to-
    non-RN ratio
      Fewer than 1 : 10
      Between 1 : 10 and
        1 : 5
      Greater than 1 : 5
  Registered nurse
      (RN)-to-resident ratio
      Fewer than 1 : 20         1.41   (1.11, 1.78) *
      Between 1 : 20 and        1.11   (0.92, 1.35)
        1 : 10
      Greater than 1 : 10       1.00   (1.00, 1.00)
  Pharmacist onsite once
    a week
      Yes
      No
  Psychologist or
    psychiatrist onsite
      once a week
      Yes
      No
  Selected technological
    services offered
    ([paragraph])
      3 or 4 services
      2 services
      1 service
      None
  Influenza vaccination
    percentage
      90 percent and
        higher
      75 percent to < 90
        percent
      Less than 75
        percent
  Census region
      Northeast
      Midwest
      South
      West
  Metropolitan statistical
    area
      Yes                       0.81   (0.65, 1.01) ([yen])
      No                        1.00   (1.00, 1.00)
  Nursing home beds
    available (#)
      5 and fewer
      > 5 to 10
      > 10 to 15
      > 15 to 20
      More than 20
  County-level income
    per capita (in $1,000s)
      Less than or equal        1.31   (0.91, 1.87)
        20
      > 20 to 25                1.35   (0.99, 1.85) ([yen])
      > 25 to 30                1.49   (1.09, 2.05) *
      More than 30              1.00   (1.00, 1.00)

([section]) 51% of all nursing home users in 1996 (n = 3,372).
Percentages based on weighted data.

([paragraph]) Services include ventilator care, intravenous therapy,
dialysis, and tube feeding.

(#) Nursing home beds available is the number of empty beds/1,000
elderly (75  age).

([yen]) p < 0.100;

* p < 0.050;

** p < 0.001.

Source: Center for Cost and Financing Studies, Agency for Healthcare
Research and Quality, The National 1996 Medical Expenditure Panel
Survey Nursing Home Component.

 

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