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Genzyme Reports Strong First-Quarter Growth

PR Newswire,  April 23, 2008  

Non-GAAP EPS Increased 22 Percent

CAMBRIDGE, Mass., April 23 /PRNewswire-FirstCall/ -- Genzyme Corporation today reported results for the first quarter of 2008, which featured excellent revenue growth, continued operating leverage, a significant increase in non-GAAP profit, and strong progress across the company.

  First-Quarter Highlights
  -- Total revenue for the quarter grew 25 percent to $1.1 billion from
     $883.2 million in same period a year ago.  This increase was driven by
     growth across all product lines, led by strong growth in sales of
     treatments for lysosomal storage disorders and renal disease.
     Genzyme's top line now includes sales of Aldurazyme(R) (laronidase),
     which previously were recorded as joint venture revenue.

  -- GAAP net income in the first quarter was $145.3 million, or $0.52 per
     diluted share, compared with $158.2 million, or $0.57 per diluted
     share.  GAAP net income in this year's first quarter reflects an after-
     tax charge of $56.5 million for the premium related to Genzyme's
     strategic investment in Isis Pharmaceuticals Inc.

  -- Non-GAAP net income increased 24 percent to $260.9 million, compared
     with $210.7 million in the first quarter a year earlier.  Non-GAAP
     earnings increased 22 percent to $0.95 per diluted share from $0.78 per
     diluted share in the first quarter last year.

  -- Non-GAAP operating expenses decreased as a percentage of revenue,
     reflecting global operating leverage.

  -- Genzyme continued to generate significant cash from operations and to
     reinvest in the future of the company.  In the first quarter, Genzyme
     generated approximately $373 million in cash from net income prior to
     one-time events and proceeds from the issuance of common stock.  The
     company invested approximately $122 million in capital projects to
     expand manufacturing capacity to meet current and anticipated product
     demand.  The company also made a $150 million investment in Isis
     Pharmaceuticals associated with the license of mipomersen, a highly
     promising product candidate in late-stage development.

  -- Genzyme is also using a portion of its operating cash flow to
     repurchase shares under a three-year program to reduce the dilutive
     effect of equity compensation.  The company repurchased 1 million
     shares in the first quarter and has repurchased approximately 4.5
     million shares since this program began one year ago.



"We had a very strong first quarter to start the year," said Henri A. Termeer, Genzyme's chairman and chief executive officer. "We continue to focus on our commitment to deliver 20 percent non-GAAP earnings growth through 2011, while building the company to ensure that we sustain our growth over the longer term."