Efectos del ciclamato de sodio en el hígado fetal de ratas estudios cariometico y estreologico

International Journal of Morphology, Sept, 2005 by Alex Tadeu Martins, Reinaldo Azoubel, Ruberval A. Lopes, Miguel A. Sala di Matteo, José Germano Ferraz de Arruda

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Correspondence to:

Prof. Dr. Reinaldo Azoubel

Faculdade de Medicina de São José do Rio Preto (FAMERP)

Av. Brigadeiro Faria Lima, 5416

CEP 15090-000

São José do Rio Preto--SP BRAZIL

Tel.: 55 17 3201 5712

Email: alex@feb.br

Received : 15-01-2005

Accepted: 20-05-2005

* Alex Tadeu Martins; *Reinaldo Azoubel; ** Ruberval A. Lopes; ** Miguel A. Sala di Matteo & * José Germano Ferraz de Arruda

* Faculdade de Medicina de São José do Rio Preto (FAMERP), Sao José do Rio Preto, SP, Brazil.

** Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo (FORP-USP), Ribeirão Preto, SP, Brazil.

Table I. Mean values for fetal weight and placental weight (g);
umbilical-cord length (cm) of control fetuses (C) and treated with
sodium cyclamate (T). Mann-Whitney test.

Parameter                Control    Treated     U     P[U]

Fetal weight               2.94       2.31     0 *    0.004
Placental weight           0.44       0.29     0 *    0.004
Umbilical cord length      2.12       1.93     0 *    0.004

* [alfa] <0.01

Table II. Mean values for major, minor and mean diameters ([micrón]m),
and the ratio between major and minor diameter, volume
([micrón][m.sup.3]), area ([micrón][m.sup.2]), perimeter (mm),
volume-area ratio, eccentricity, shape factor and contour index for
the liver of rat fetuses for control (C) and those treated with sodium
cyclamate (T). Mann-Whitney test.

Parameter                      Control    Treated     U      P[U]

Major diameter                   11.58      12.69     0 *    0.004
Minor diameter                    8.59       9.63     0 *    0.004
Meat diameter                     9.94      11.02     0 *    0.004
Major-minor diameter ratio        1.37       1.34     8ns    0.21
Volume                          543.92     739.73     0 *    0.004
Area                             79.09      97.12     0 *    0.004
Perimeter                        31.9       35.27     0 *    0.004
Volume-area ratio                 6.63       7.35     0 *    0.004
Eccentricity                      0.64       0.62     9ns    0.274
Shape factor                      0.96       0.96     9ns    0.274
Contour Index                     3.62       3.61    10ns    0.345

* [alfa] < 0.001 ns = not significant

Table III. Mean values of nucleus-cytoplasm ratio, cytoplasmic volume
(mm3), cellular volume ([micrón][m.sup.3]), numerical cellular density
(n[grados]/[micrón][m.sup.3]) of the liver of control rats (C) and
those treated with sodium cyclamate (T). Mann-Whitney test.

Parameter                     Control       Treated     U       P[U]

Nucleus-cytoplasm ratio            0.314       0.216    3 **    0.028
Cytoplasm volume                1645.76     2533.97     0 *     0.004
Cellular volume                 2189.67     3273.7      0 *     0.004
Numerical cellular density    472262.6       307.146    0 *     0.004

* [alfa] <0.01; ** [alfa] <0.05