WelChol(R), In Combination With Lipitor(R), Cuts LDL Cholesterol Levels By 48%

Market Wire, 20050229

It discovered, co-developed and manufactures pravastatin. Sankyo independently markets pravastatin throughout the world and through its licensee, Bristol-Myers Squibb. Pravastatin is marketed as Pravachol(R) in the United States.

*Please see package insert for full prescribing information.

Mevacor(R) and Zocor(R) are registered trademarks of Merck & Co., Inc.; Lipitor(R) is a registered trademark of Pfizer Inc.; Pravachol(R) is a registered trademark of Bristol-Myers Squibb Co.

References Hunninghake, Donald, Insull, William, Toth, Phillip, Davidson, David, Donovan, Joanne, Burke, Steven. Coadministration of Colesevelam Hydrochloride with Atorvastatin Lowers LDL Cholesterol Additively. Atherosclerosis. April 1, 2001; 110:352-360.

2. Knapp, H et al. Efficacy and Safety of Combination Simvastatin and Colesevelam in Patients with Primary Hypercholesterolemia. American Journal of Medicine. April 1, 2001; 110::352-360

3. Davidson, Michael, Toth, Phillip, Weiss, Stuart, McKenney, James, Hunninghake, Donald, Isaacsohn, Jonathan, Donovan, Joanne, Burke, Steven. Low-Dose Combination therapy with Colesevelam Hydrochloride and Lovastatin Effectively Decreases Low-Densitiy Lipoprotein Cholesterol in Patients with Primary Hypercholesterolemia. Clinical Cardiology. June, 2001; 24:467-474.