Senomyx, Inc. Fourth Quarter and Fiscal Year-End 2007 Earnings Conference Call Scheduled for February 7, 2008

Market Wire, January, 2008

Senomyx, Inc. (NASDAQ: SNMX) will release its financial results for the fourth quarter and fiscal year ending December 31, 2007 on Thursday, February 7, 2008 before the opening of the U.S. financial markets. The Company will also host a conference call and live audio webcast at 11:00 a.m. Eastern Time (8:00 a.m. Pacific Time) that same day. During the call, Senomyx's management will provide a business update and will discuss the financial results for the fourth quarter and year-end 2007 and financial guidance for 2008.

To participate in the live conference call, U.S. residents should dial 888-713-4209, and international callers should dial 617-213-4863, at least 10 minutes prior to the call start time. The participant passcode for this conference call is 78693966. Participants may pre-register for the call at anytime, including up to and after the call start time, at https://www.theconferencingservice.com/prereg/key.process?key=PBTQB9TKR . Pre-registrants will be issued a pin number to use when dialing into the live call, which will provide quick access to the conference.

To access the live Internet broadcast or a subsequent archived recording, please log onto Senomyx's website at http://www.senomyx.com and click on the Investor Relations tab. The archived webcast will be available for 30 days following the presentation. Please connect to Senomyx's website prior to the start of the webcast to ensure adequate time to download any software that may be necessary.

About Senomyx, Inc. ( www.senomyx.com )

Senomyx is a leading company using proprietary taste receptor technologies to discover and develop novel flavor ingredients in the savory, sweet, salt, bitter and cooling areas. Senomyx has entered into product discovery and development collaborations with seven of the world's leading food, beverage, and ingredient supply companies: Ajinomoto Co., Inc., Cadbury Schweppes, Campbell Soup Company, The Coca-Cola Company, Firmenich SA, Nestlé SA, and Solae, LLC. Nestlé is currently marketing products that contain one of Senomyx's flavor ingredients. For more information, please visit www.senomyx.com .

Contact: Gwen Rosenberg Senomyx, Inc. Vice President, Investor Relations & Corporate Communications 858-646-8369 Email Contact