Symyx Technologies to Announce 2008 Second Quarter Financial Results

Symyx Technologies, Inc. (NASDAQ: SMMX) announced today that it will release second quarter 2008 results on Wednesday, July 30, 2008.

Isy Goldwasser, chief executive officer, and Rex Jackson, executive vice president and chief financial officer, will host a webcast at 5:00 pm ET/2:00 pm PT, to discuss Symyx's recent business and financial results and outlook. A question and answer session will follow immediately.

A live audio webcast of the event and slide show presentation will accompany management's discussion and will be available through the investors section of the Symyx website at www.symyx.com . For audio only, the dial-in numbers are 877-591-4956 (U.S. and Canada) and 719-325-4874 (international). Interested parties may access a replay which will be available for approximately two weeks on Symyx's website or by dialing 888-203-1112 (U.S. and Canada) and 719-457-0820 (international), reservation 2453996. The webcast and audio are open to all interested parties.

About Symyx

Symyx Technologies, Inc. is the scientific R&D integration partner to companies in the life sciences, chemicals, energy, electronics and consumer products industries. With scientific R&D under tremendous economic and technical pressure, we help companies reduce R&D risk and enhance R&D productivity to help them bring more and better products to market quickly and cost-effectively. Our integrated technology platform combines electronic laboratory notebooks, content, laboratory logistics and analysis available from Symyx Software, software-driven integrated workflows available from Symyx Tools and collaborative research and directed services from Symyx Research to support the entire R&D process. In October 2007, Symyx acquired MDL Information Systems, Inc., a leading provider of innovative informatics software, databases and services that accelerate successful scientific R&D by improving the speed and quality of scientists' decision making. Information about Symyx, including reports and other information filed by Symyx with the Securities and Exchange Commission, is available at www.symyx.com .

For More Information: Rex S. Jackson EVP and CFO Symyx Technologies, Inc. (408) 773-4075 Email Contact