Health Care Industry

Effect of phorbol myristate acetate (PMA) and ionophore A23187 on interleukin-2 levels and proliferation of activated T lymphocytes from patients with lepromatous leprosy

International Journal of Leprosy and Other Mycobacterial Diseases, Mar 1997 by Fernando Alfaro-Bustamante, Gabriela Ramirez-Flores, Amado Gonzalez-Mendoza, Alfonso Islas-Rodriguez, Mary Fafutis-Morris

3. ALBERTS, B., BRAY, D., LEWIS, J., RAFF, M., ROBERTS, K. and WATSON, J. D. Molecular Biology of the Cell. 2nd edn. New York: Garland Publishing, 1989.

4. BAZZI, M. D. and NELSESTUEN, G. L. Constitutive activity of membrane-inserted protein kinase C. Biochem. Biophys. Res. Comm. 152 (1988) 336-343.

5. BERRY, N., ASE, K., KIKKAWA, U., KISHIMOTO, A. and NISHIZUKA, Y. Human T cell activation by phorbol esters and diacylglycerol analogues. J. Immunol. 143 (1989) 1407-1413. 6. Boyum, A. Isolation of mononuclear cells and granulocytes from human blood. Scan. J. Clin. Lab. Invest. 21 Suppl.197 (1988) 7785. 7. CHAUHAN, A., CHAUHAN, V. P. S., DESHMUKH, D. S. and BROCKERHOFF, B. Phosphatidylinositol 4,5-biphosphate competitively inhibits phorbol ester binding to protein kinase C. Biochemistry 28 (1989)4952-4956.

Most RecentHealth Care Articles

8. FIELDS, P. E., GAJEWSKI, T. F and FITCH, F W. Blocked Ras activation in anergic CD4 T cells. Science 271 (1996) 1276-1278. 9. HAREGEWOIN, A., MUSTAFA, A. S., HELLE, I., WATERS, M. F., LEIKER, D. L. and GODAL, T. Reversal by interleukin-2 of the T-cell unresponsiveness of lepromatous leprosy to Mycobacterium leprae. Immunol. Rev. 80 (1984) 76-86.

10. HASTINGS, R. C., GILLIS, T. P., KRAHENBUHL, J. L. and FRANZBLAU, S. G. Leprosy. Clin. Microbiol. Rev. 1 (1988) 330-348.

II. ISAKOV, N. and ALTMAN, A. Human T lymphocyte activation by tumor promoters: role of protein kinase C. J. Immunol. 138 (1987) 3100-3107.

12. ISLAS, R. A., MORALES, O. R., FAFUTIS, M. M., GONZALEZ, M. A. and ORTIZ, O. L. Deficiency in the biosynthesis of interleukin 2 (IL-2) and functional presence of the IL-2 receptor in lepromatous leprosy. Int. J. Lepc 55 (1987) 566-569. 13. KORETSKY, G. A., DANIELE, R. P., GREENE, W. C. and NOWELL, P. C. Evidence for an interleukin-independent pathway for human lymphocyte activation. Proc. Natl. Acad. Sci. U.S.A. 80 (1983) 3444-3447.

14. LI, W., WHALEY, C. D., MONDINO, A. and MUELLER, D. Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4 T cells. Science 271 (1996) 1272-1276. 15. MEAGER, A. Cytokines. Buckingham, U.K.: Open

University Press, 1990.

16. MILLS, G. B., CHEUNG, R. K., GRINSTEIN, S. and GELFAND, E. W. Increase in cytosolic free calcium concentration is an intracellular messenger for the production of interleukin 2 but not for the expression of the interleukin 2 receptor. J. Immunol. 134 (1985) 1640-1643.

17. MILLS, G. B., MAY, C., HILL, M. and GELFAND, E. W. Role of protein kinase C in interleukin 1, antiT3, mitogenic lectin-induced interleukin 2 secretion. J. Cell. Physiol. 141 (1989) 310-317. 18. MILLS, G. B., STEWART, D. J., MELLORS, A. and GELFAND, E. W. Interleukin 2 does not induce phosphatidylinositol hydrolysis in activated T cells. J. Immunol. 136 (1986) 3019-3024. 19. MOHAGHEGHPOUR, N., GELBER, R. H. and ENGLEMAN, E. G. T cell defect in lepromatous leprosy is reversible in vitro in the absence of exogenous growth factors. J. Immunol. 138 (1987) 570-574.

20. Quantikine Human IL-2 Immunoassay. Minneapolis, Minnesota, U.S.A.: R & D Systems, 1994. 21. RIDLEY, D. S. and JOPLING, W. H. Classification of leprosy according to immunity: a five-group system. Int. J. Lepr. 34 (1966) 255-273. 22. SCHWARTZ, R. H. Anergia de las celulase T. Invest. Cien. 205 (1993) 24-31.