Wake up and smell the coffee: Oklahoma Medical Research Foundation

Journal Record, The (Oklahoma City), Jul 2, 2008

A new study co-authored by Oklahoma Medical Research Foundation scientist Linda Thompson found that mice immunized to develop a multiple sclerosis-like condition were protected from the disease by drinking caffeine.

The research appears in the online edition of Proceedings of the National Academy of Sciences.

In the study, researchers followed the progress of mice that normally developed an MS-like condition. The scientists discovered that when the rodents consumed the equivalent of six to eight cups of coffee a day, they did not develop the condition.

The finding could lead to new ways to prevent and treat MS, said Thompson.

According to Thompson, the caffeine stopped adenosine - one of the four building blocks in DNA - from binding to an adenosine receptor in mice. Adenosine is a common molecule in the human body and plays a vital part in the biochemical processes of sleep, suppression of arousal and energy transfer.

"This is an exciting and unexpected finding, and I think it could be important for the study of MS and other diseases," said Thompson, who holds the Putnam City Schools Distinguished Chair in Cancer Research at OMRF.

She said the research holds potential for lupus, rheumatoid arthritis and other autoimmune diseases - conditions in which the body uses the weapons of its immune system against itself.

While the results are heartening, Thompson said there is much more work to be done for the prevention of multiple sclerosis in humans.

"A mouse is not a human being, so we can't be sure caffeine will have the same effect on people prone to develop MS without much more testing," she said.