Imagination, science help paralyzed man move

0 Comments | Deseret News (Salt Lake City), Jul 13, 2006 | by Tom Avril The Philadelphia Inquirer

With the aid of electrodes implanted in his brain, a man paralyzed from the neck down was able to perform certain everyday activities -- move a computer cursor, open e-mail, turn on a TV set - - merely by imagining them.

The patient, whose spinal cord was injured when an attacker stabbed him in the neck, was even able to open and close a prosthetic hand, his thoughts translated into action by a custom- built computer.

For now, the patient must be tethered to a cart loaded with electronics. The system was developed by scientists at Brown University, who say it is just a few years away from commercial use.

The results, reported in Thursday's issue of the journal Nature, offer hope that thousands of people with injured spinal cords could someday regain significant function by simply bypassing the injury. Eventually the team expects patients will have a wireless device implanted in the brain that sends signals not just to computers, but to parts of their own bodies.

Coincidentally, Wednesday, a team that includes Drexel University scientists reported progress toward a similar goal in lab rats, albeit by different means. The researchers removed a nerve from each animal's leg and transplanted it across the injured spinal cord, restoring some mobility to paralyzed forelimbs.

Meanwhile, the efforts of the Brown University team, which included researchers in Chicago and Massachusetts, seem like something out of science fiction.

After implanting electrodes in the brain of Matthew Nagle, the 25- year-old stabbing victim, scientists discovered that the neurons associated with moving his arms and hands could still generate electrical signals -- a surprising find, three years after the attack.

They ran wires through his skull to BrainGate, an electronic device that filtered out the noise and learned to interpret the signals. When connected to a computer, Nagle was able to play the video game "Pong" and also drew a circle using a computer drawing program.

"I just imagined moving the cursor," he said in a telephone interview, from his room in a Massachusetts rehab hospital.

The goal is to make a wireless device that could be fully implanted so the patient would not have to be wired to a computer -- much like with cochlear implants, the devices that can help deaf people perceive sound.

One hitch is that the array of electrodes implanted in Nagle's brain seems to have suffered a short-circuit toward the end of the 14-month experiment.

The breakdown was not caused by any adverse reaction in the brain itself, John Donoghue of Brown University in Providence, co-author of the patient study, said.

"The barriers to this seem more technological, but surmountable, rather than anything biological," he said. "I'm very encouraged."

While the current work involves moving computer cursors and prosthetic devices, the researchers hope someday to transmit electrical signals from the brain to a patient's real hands and arms.

Nagle's parents were somewhat apprehensive about the brain implant but he was determined to press forward.

The electrodes were removed after the experiment, so he no longer can bypass his crippling injury with the futuristic BrainGate. But Nagle's participation was not just about bettering his own condition, he said, his voice a hoarse rasp because he breathes with a ventilator.

"I knew it would give a lot of people hope," Nagle said.